Steven J. Novick

TL;DR: A scale based on the Black and Leff operational model that contains the key elements required to describe 7TM agonism, namely, affinity for the receptor and efficacy in activating a particular signaling pathway, can statistically evaluate selective agonist effects in a manner that can theoretically inform structure-activity studies and/or drug candidate selection matrices.

TL;DR: Evaluating drug effects on hERG channels is best performed by electrophysiological methods and the IonWorks Barracuda provides an efficient way to study hERG biophysics and pharmacology.

TL;DR: The acute XF assay is demonstrated to be a robust, sensitive screening platform for evaluating drug-induced effects on mitochondrial activity in whole cells and validated using marketed drugs known to modulate mitochondrial function.

TL;DR: The results show that coverages are needed for a batch to have acceptance probability 98% or greater with the test named by the FDA “87.5% coverage” (95% confidence level), while batches with 87.

TL;DR: The method uses a two one-sided test of equivalence to evaluate the bias that can result from approximating a higher-order polynomial response with a linear function, and provides a closed-form solution, thus making linearity testing easy to implement.