S
Steven M. Ruben
Researcher at Human Genome Sciences
Publications - 185
Citations - 4690
Steven M. Ruben is an academic researcher from Human Genome Sciences. The author has contributed to research in topics: Nucleic acid & Chemokine. The author has an hindex of 20, co-authored 185 publications receiving 4645 citations. Previous affiliations of Steven M. Ruben include GlaxoSmithKline.
Papers
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Journal ArticleDOI
Mutation of a mutL homolog in hereditary colon cancer
Nickolas Papadopoulos,Nicholas C. Nicolaides,Ying Fei Wei,Steven M. Ruben,Kenneth C. Carter,Craig A. Rosen,William A. Haseltine,Robert D. Fleischmann,Claire M. Fraser,Mark Raymond Adams,J. Craig Venter,Stanley R. Hamilton,Gloria M. Petersen,Patrice Watson,Henry T. Lynch,Päivi Peltomäki,Jukka-Pekka Mecklin,Albert de la Chapelle,Kenneth W. Kinzler,Bert Vogelstein +19 more
TL;DR: A search of a large database of expressed sequence tags derived from random complementary DNA clones revealed three additional human mismatch repair genes, all related to the bacterial mutL gene, demonstrating that this gene is responsible for HNPCC.
Journal ArticleDOI
Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.
Nicholas C. Nicolaides,Nickolas Papadopoulos,Bo Liu,Ying Fei Weit,Kenneth C. Carter,Steven M. Ruben,Craig A. Rosen,William A. Haseltine,Robert D. Fleischmann,Claire M. Fraser,Mark Raymond Adams,J. Craig Venter,Malcolm G. Dunlop,Stanley R. Hamilton,Gloria M. Petersen,Albert de la Chapelle,Bert Vogelstein,Kenneth W. Kinzler +17 more
TL;DR: Two additional homologues of the prokaryotic mutL gene were found to be mutated in the germline of HNPCC patients, which doubles the number of genes implicated in H NPCC and may help explain the relatively high incidence of this disease.
Patent
Antibodies that immunospecifically bind BLyS
TL;DR: In this paper, the authors present methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B lymphocyte stimulator.
Patent
Interleukins-21 and 22
Reinhard Ebner,Steven M. Ruben +1 more
TL;DR: In this article, the authors proposed a method to produce human proteins designated Interleukin-21 (IL-21) and Interleuxin-22(IL-22) and isolated polynucleotides encoding these proteins.
Patent
Albumin fusion proteins comprising GLP-1 polypeptides
TL;DR: The present invention encompasses albumin fusion proteins as mentioned in this paper, as well as vectors containing these nucleic acids, host cells transformed with the nucleic acid vectors, and methods of making the fusion proteins of the invention.