S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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Journal ArticleDOI
The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD +
Zachary Gerhart-Hines,Zachary Gerhart-Hines,John E. Dominy,Sharon M. Blättler,Mark P. Jedrychowski,Alexander S. Banks,Ji Hong Lim,Helen Chim,Steven P. Gygi,Pere Puigserver +9 more
TL;DR: A cAMP-induced phosphorylation of a highly conserved serine (S434) located in the SIRT1 catalytic domain that rapidly enhanced intrinsic deacetylase activity independently of changes in NAD(+) levels is identified.
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BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number
Lea M. Starita,Yuka Machida,Satish Sankaran,Joshua E. Elias,Karen Griffin,Brian P. Schlegel,Steven P. Gygi,Jeffrey D. Parvin +7 more
TL;DR: Results showed that centrosome components, including γ-tubulin, are ubiquitinated by BRCA1/BARD1 in vitro, which supports the notion that the modification of these lysines in living cells is critical in the maintenance of centrosomes.
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Serum‐stimulated, rapamycin‐sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI
Brian Raught,Anne-Claude Gingras,Steven P. Gygi,Hiroaki Imataka,Shigenobu Morino,Alessandra Gradi,Ruedi Aebersold,Nahum Sonenberg +7 more
TL;DR: Two‐dimensional phosphopeptide mapping demonstrates that the phosphorylation state of specific eIF4GI residues is altered by serum and mitogens, and suggests that the accessibility of the C‐terminus to kinases is modulated by this pathway(s).
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A Stress-Responsive System for Mitochondrial Protein Degradation
Jin-Mi Heo,Nurit Livnat-Levanon,Eric B. Taylor,Kevin T. Jones,Noah Dephoure,Julia Ring,Jianxin Xie,Jeffrey L. Brodsky,Frank Madeo,Steven P. Gygi,Kaveh Ashrafi,Michael H. Glickman,Jared Rutter +12 more
TL;DR: It is demonstrated that Ydr049 (renamed VCP/Cdc48-associated mitochondrial stress-responsive--Vms1), a member of an unstudied pan-eukaryotic protein family, translocates from the cytosol to mitochondria upon mitochondrial stress.
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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
Alison E. Ringel,Jefte M. Drijvers,Jefte M. Drijvers,Gregory J. Baker,Alessia Catozzi,Alessia Catozzi,Juan Carlos García-Cañaveras,Brandon M. Gassaway,Brian C. Miller,Brian C. Miller,Vikram R. Juneja,Vikram R. Juneja,Thao H. Nguyen,Thao H. Nguyen,Shakchhi Joshi,Cong-Hui Yao,Haejin Yoon,Peter T. Sage,Peter T. Sage,Martin W. LaFleur,Martin W. LaFleur,Justin D. Trombley,Justin D. Trombley,Connor A. Jacobson,Zoltan Maliga,Steven P. Gygi,Peter K. Sorger,Joshua D. Rabinowitz,Arlene H. Sharpe,Arlene H. Sharpe,Marcia C. Haigis +30 more
TL;DR: It is demonstrated that high-fat diet (HFD)-induced obesity impairs CD8+ T cell function in the murine TME, accelerating tumor growth and blocking metabolic reprogramming by tumor cells in obese mice improves anti-tumor immunity.