S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin,Raphael J. Bruckner,José Navarrete-Perea,Joe R. Cannon,Joe R. Cannon,Kurt Baltier,Fana Gebreab,Melanie P. Gygi,Alexandra Thornock,Gabriela Zarraga,Stanley Tam,John Szpyt,Alexandra Panov,Hannah Parzen,Sipei Fu,Arvene Golbazi,Eila Maenpaa,Keegan Stricker,Sanjukta Guha Thakurta,Ramin Rad,Joshua Pan,David P. Nusinow,Joao A. Paulo,Devin K. Schweppe,Laura Pontano Vaites,J. Wade Harper,Steven P. Gygi +26 more
TL;DR: Through affinity-purification mass spectrometry, two proteome-scale, cell-line-specific interaction networks are created that define principles of proteome organization and enable unknown protein characterization.
Journal ArticleDOI
Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response.
Andrew E. H. Elia,Alexander P. Boardman,Alexander P. Boardman,David C. Wang,David C. Wang,Edward L. Huttlin,Robert A. Everley,Noah Dephoure,Chunshui Zhou,Itay Koren,Steven P. Gygi,Stephen J. Elledge +11 more
TL;DR: This work finds that K6- and K33-linked polyubiquitination undergo bulk increases in response to DNA damage, raising the possibility that these linkages are largely dedicated to DDR function, and shows that Cullin-RING ligases mediate 10% of DNA damage-induced ubiquitination events.
Journal ArticleDOI
Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation.
TL;DR: The results suggest that Set2 through association with the elongating form of RNA polymerase II plays an important role in transcription elongation.
Journal ArticleDOI
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.
Tingting Sun,Nicola Aceto,Kristen L. Meerbrey,Jessica D. Kessler,Chunshui Zhou,I. Migliaccio,Don X. Nguyen,Natalya N. Pavlova,Maria F. Botero,Jian Huang,Ronald J. Bernardi,Earlene M. Schmitt,Guang Hu,Mamie Z. Li,Noah Dephoure,Steven P. Gygi,Mitchell Rao,Chad J. Creighton,Susan G. Hilsenbeck,Chad A. Shaw,Donna M. Muzny,Richard A. Gibbs,Richard A. Gibbs,David A. Wheeler,David A. Wheeler,C. Kent Osborne,Rachel Schiff,Mohamed Bentires-Alj,Stephen J. Elledge,Thomas F. Westbrook +29 more
TL;DR: PTPN12 is identified as a commonly inactivated tumor suppressor in triple-negative breast cancer and a rationale for combinatorially targeting proto-oncogenic tyrosine kinases in TNBC and other cancers based on their profile of tyosine-phosphatase activity is provided.
Journal ArticleDOI
Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells.
Duan-Fang Liao,Zheng Gen Jin,Arnold S. Baas,Guenter Daum,Steven P. Gygi,Ruedi Aebersold,Bradford C. Berk +6 more
TL;DR: Results show that brief oxidative stress causes sustained release of protein factors from VSMC that can stimulate ERK1/2 activation, and these factors may be important mediators for the effects of reactive oxygen species on vascular function.