S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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Why do cellular proteins linked to K63‐polyubiquitin chains not associate with proteasomes?
TL;DR: It is shown that mammalian cells contain soluble factors that selectively bind to K63 chains and inhibit or prevent their association with proteasomes and the Rad23 proteins, especially hHR23B, were found to bind specifically to K48‐ubiquitinated proteins and to stimulate proteasome binding.
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Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
Pengda Liu,Wenjian Gan,Hiroyuki Inuzuka,Adam S. Lazorchak,Daming Gao,Omotooke Arojo,Dou Liu,Lixin Wan,Bo Zhai,Yonghao Yu,Yonghao Yu,Min Yuan,Byeong Mo Kim,Shavali Shaik,Suchithra Menon,Steven P. Gygi,Tae Ho Lee,John M. Asara,Brendan D. Manning,John Blenis,Bing Su,Wenyi Wei +21 more
TL;DR: Results reveal a Sin1-phosphorylation-dependent mTORC2 regulation, providing a potential molecular mechanism by which mutations in the m TORC1–S6K–Sin1 signalling axis might cause aberrant hyper-activation of the mtorC2–Akt pathway, which facilitates tumorigenesis.
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Genomic and Proteomic Profiling Reveals Reduced Mitochondrial Function and Disruption of the Neuromuscular Junction Driving Rat Sarcopenia
Chikwendu Ibebunjo,Joel M. Chick,Tracee L. Kendall,John K. Eash,Christine Li,Yunyu Zhang,Chad Vickers,Zhidan Wu,Brian A. Clarke,Jun Shi,Joseph Cruz,Brigitte Fournier,Sophie Brachat,Sabine Gutzwiller,QiCheng Ma,Judit Markovits,Michelle Broome,Michelle Steinkrauss,Elizabeth Skuba,Jean-Rene Galarneau,Steven P. Gygi,David J. Glass +21 more
TL;DR: It is suggested that therapeutic approaches that simultaneously stimulate mitochondrogenesis and reduce muscle proteolysis and inflammation have potential for treating sarcopenia.
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Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization
Wen Yang,Koji Nagasawa,Koji Nagasawa,Christian Münch,Yingjie Xu,Kyle Satterstrom,Seung Min Jeong,Sebastian D. Hayes,Mark P. Jedrychowski,F. Sejal Vyas,Elma Zaganjor,Virginia Guarani,Alison E. Ringel,Steven P. Gygi,J. Wade Harper,Marcia C. Haigis +15 more
TL;DR: The SIRT3-5 interaction network provides a framework for discovering novel biological functions regulated by mitochondrial sirtuins and identifies candidate sirtuin substrates, and uncovers a fundamental role for sequestration by ATP synthase in mitochondrial homeostasis.
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Protein Profiling with Cleavable Isotope-coded Affinity Tag (cICAT) Reagents The Yeast Salinity Stress Response
TL;DR: The results indicate that salt stress and amino acid starvation cause overlapping cellular responses and are likely to be physiologically linked.