S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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Journal ArticleDOI
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC
Nagi G. Ayad,Susannah Rankin,Monica Murakami,Judith A. Jebanathirajah,Steven P. Gygi,Marc W. Kirschner +5 more
TL;DR: Tome-1 appears to be acting as part of an SCF-type E3 for wee1, providing a critical link between the APC and SCF pathways in regulation of cdk1/cyclin B activity and thus mitotic entry and exit.
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Phosphorylation by Casein Kinase I promotes the turnover of the Mdm2 oncoprotein via the SCFβ-TRCP ubiquitin ligase
Hiroyuki Inuzuka,Alan Tseng,Daming Gao,Bo Zhai,Qing Zhang,Shavali Shaik,Lixin Wan,Xiaolu L. Ang,Caroline Mock,Haoqiang Yin,Haoqiang Yin,Jayne M. Stommel,Steven P. Gygi,Galit Lahav,John M. Asara,Zhi Xiong Jim Xiao,William G. Kaelin,J. Wade Harper,Wenyi Wei +18 more
TL;DR: It is reported that Mdm2 is rapidly degraded after DNA damage and that phosphorylation of MDM2 by casein kinase I (CKI) at multiple sites triggers its interaction with, and subsequent ubiquitination and destruction, by SCF(beta-TRCP).
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A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development
Peter Mulligan,Fajun Yang,Luisa Di Stefano,Jun-Yuan Ji,Jian Ouyang,Joy L. Nishikawa,Debra Toiber,Madhura Kulkarni,Qun Wang,S. Hani Najafi-Shoushtari,Raul Mostoslavsky,Steven P. Gygi,Grace Gill,Nicholas J. Dyson,Anders M. Näär +14 more
TL;DR: A SIRT1 corepressor complex containing the histone H3K4 demethylase LSD1/KDM1A and several other LSD1-associated proteins is described, offering new insights into conserved mechanisms of epigenetic gene repression and regulation of development by Sirt1 in metazoans.
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A novel role for RIP1 kinase in mediating TNFα production
Dana E. Christofferson,Yan Li,Junichi Hitomi,Wen Zhou,C. Upperman,Hong Zhu,Scott A. Gerber,Steven P. Gygi,Junying Yuan +8 more
TL;DR: A novel role for RIP1 kinase in regulating TNFα production after caspase inhibition is proposed and this pathway is independent of nuclear factor κB and also occurs after Smac mimetic/IAP antagonist treatment or the loss of TNF receptor-associated factor 2 (Traf2).
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Chaperone-mediated pathway of proteasome regulatory particle assembly
Jeroen Roelofs,Soyeon Park,Wilhelm Haas,Geng Tian,Fiona E. McAllister,Ying Huo,Byung-Hoon Lee,Fan Zhang,Yigong Shi,Steven P. Gygi,Daniel Finley +10 more
TL;DR: It is shown that in the yeast Saccharomyces cerevisiae three proteins are found associated with RP but not with the RP–CP holoenzyme: Nas6, Rpn14 and Hsm3 are RP chaperones, and it is shown in an accompanying study that RP assembly is templated through the Rpt C termini, apparently by their insertion into binding pockets in the CP.