S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.
Longlong Si,Haiqing Bai,Melissa Rodas,Wuji Cao,Crystal Yuri Oh,Amanda Jiang,Amanda Jiang,Rasmus Møller,Daisy A. Hoagland,Kohei Oishi,Shu Horiuchi,Skyler Uhl,Daniel Blanco-Melo,Randy A. Albrecht,Wen-Chun Liu,Tristan X. Jordan,Benjamin E. Nilsson-Payant,Ilona Golynker,Justin J. Frere,James Logue,Robert Haupt,Marisa McGrath,Stuart Weston,Tian Zhang,Roberto Plebani,Roberto Plebani,Mercy Soong,Atiq Nurani,Seongmin Kim,Danni Y. Zhu,Kambez H. Benam,Kambez H. Benam,Girija Goyal,Sarah E. Gilpin,Rachelle Prantil-Baun,Steven P. Gygi,Rani K. Powers,Kenneth E. Carlson,Matthew B. Frieman,Benjamin R. tenOever,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +42 more
TL;DR: In this paper, a microfluidic bronchial-airway-on-a-chip line was used to model the human airway epithelium and pulmonary endothelium to model viral infection, strain-dependent virulence, cytokine production and the recruitment of circulating immune cells.
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An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer.
Lianfeng Wu,Ben Zhou,Noriko Oshiro-Rapley,Man Li,Joao A. Paulo,Christopher M. Webster,Fan Mou,Michael C. Kacergis,Michael E. Talkowski,Christopher E. Carr,Steven P. Gygi,Bin Zheng,Alexander A. Soukas +12 more
TL;DR: It is demonstrated that biguanide-induced inactivation of mTORC1 subsequently inhibits growth through transcriptional induction of ACAD10, which provides a unified mechanism by which metformin kills cancer cells and extends lifespan, and illuminates potential cancer targets.
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Global Analysis of Protein Expression and Phosphorylation of Three Stages of Plasmodium falciparum Intraerythrocytic Development
Brittany N. Pease,Edward L. Huttlin,Mark P. Jedrychowski,Eric Talevich,John W Harmon,Timothy Dillman,Natarajan Kannan,Christian Doerig,Ratna Chakrabarti,Steven P. Gygi,Debopam Chakrabarti +10 more
TL;DR: The constitutive and regulated expression of the Plasmodium proteome is defined, offering an insight into the dynamics of phosphorylation during asexual cycle progression, a major step toward defining kinase-substrate pairs operative in various signaling networks in the parasite.
Journal ArticleDOI
Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer
TL;DR: A possible model in which RENT, Tof2, and Lrs4/Csm1 physically clamp rDNA to the cohesin ring, thereby restricting the movement of rDNA sister chromatids relative to each other to inhibit unequal exchange is suggested.
Journal ArticleDOI
Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation
Hengyao Niu,Lihong Wan,Valeria Busygina,Youngho Kwon,Jasmina A. Allen,Xue Li,Ryan C. Kunz,Kazuishi Kubota,Beatrice Wang,Patrick Sung,Kevan M. Shokat,Steven P. Gygi,Nancy M. Hollingsworth +12 more
TL;DR: Mek1 phosphorylation provides a dynamic means of controlling recombination partner choice in meiosis in two ways: (1) it reduces Rad51 activity through inhibition of Rad51/Rad54 complex formation, and (2) it suppresses Rad51-mediated strand invasion of sister chromatids via a Rad54-independent mechanism.