Steven P. Gygi

TL;DR: This work identifies a previously unknown function of the Rpt proteins in proteasome biogenesis through deleting the C-terminal residue from each Rpt in the yeast Saccharomyces cerevisiae, and proposes that Rpt4 and Rpt6 form a nucleating complex to initiate base assembly, and that this complex is subsequently joined by BP1 to complete the RPT ring.

TL;DR: The results suggest that RSK-mediated phosphorylation of DAPK is a unique mechanism for suppressing the proapoptotic function of this death kinase in healthy cells as well as Ras/Raf-transformed cells.

TL;DR: It is demonstrated that multiple monoubiquitylation of cyclin B1, catalysed by UBCH10 or UBC4/5, is sufficient to target cyclinB1 for destruction by the proteasome.

TL;DR: The need to investigate further ion interference-generated ratio distortion and promote the TKO standard as a tool to investigate such issues is emphasized.

TL;DR: Using quantitative proteomics, this work uncovers a previously unrecognized subunit of the MICOS complex, necessary for CJ integrity, cristae morphology, and mitochondrial function and provides a resource for further analysis of MICOS architecture.