S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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Journal ArticleDOI
Regulation of MicroRNA Machinery and Development by Interspecies S-Nitrosylation
Puneet Seth,Paishiun N. Hsieh,Suhib Jamal,Liwen Wang,Steven P. Gygi,Mukesh K. Jain,Jeff Coller,Jonathan S. Stamler,Jonathan S. Stamler +8 more
TL;DR: The microbiota can shape the post-translational landscape of the host proteome to regulate microRNA activity, gene expression, and host development, and suggest a general mechanism by which the microbiota may control host cellular functions, as well as a new role for gasotransmitters.
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PIASy Mediates SUMO-2/3 Conjugation of Poly(ADP-ribose) Polymerase 1 (PARP1) on Mitotic Chromosomes
Hyunju Ryu,Gada Al-Ani,Katelyn Deckert,Donald S. Kirkpatrick,Steven P. Gygi,Mary Dasso,Yoshiaki Azuma +6 more
TL;DR: A novel SUMO-2/3-modified mitotic chromosomal protein is isolated and identified as poly(ADP-ribose) polymerase 1 (PARP1), and a residue within the BRCA1 C-terminal domain of PARP1 (lysine 482) is identified as its primary SUMOylation site.
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MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice
Weiguo Zou,Matthew B. Greenblatt,Jae-Hyuck Shim,Shashi Kant,Bo Zhai,Sutada Lotinun,Nicholas J. Brady,Dorothy Hu,Steven P. Gygi,Roland Baron,Roger J. Davis,Dallas C. Jones,Laurie H. Glimcher +12 more
TL;DR: The results provide a putative biochemical mechanism for the skeletal defects in human FGDY and suggest that modulating MAPK signaling may benefit these patients.
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Survey of Activated FLT3 Signaling in Leukemia
Ting-Lei Gu,Julie Nardone,Yi Wang,Marc M. Loriaux,Judit Villén,Sean A. Beausoleil,Meghan Ann Tucker,Jon M. Kornhauser,Jianmin Ren,Joan MacNeill,Steven P. Gygi,Brian J. Druker,Brian J. Druker,Michael Heinrich,Michael Heinrich,John Rush,Roberto D. Polakiewicz +16 more
TL;DR: It is shown that oncogenic FLT3 regulates proteins involving diverse cellular processes and affects multiple signaling pathways in human leukemia that were previously appreciated, such as Fc epsilon RI-mediated signaling, BCR, and CD40 signaling pathways.
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C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.
Wei Chung Chiang,Daniel X. Tishkoff,Bo Yang,Joshua T. Wilson-Grady,Xiaokun Yu,Travis Mazer,Mark Eckersdorff,Steven P. Gygi,David B. Lombard,Ao Lin Hsu +9 more
TL;DR: SIR-2.4 is identified as a critical regulator of DAF-16 specifically in the context of stress responses, and a novel role for acetylation is revealed, modulated by the antagonistic activities of CBP-1 and SIR- 2.4, in modulating D AF-16 localization and function.