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Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
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Journal ArticleDOI
Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.
Binkai Chi,Jeremy D. O’Connell,Jeremy D. O’Connell,Tomohiro Yamazaki,Jaya Gangopadhyay,Steven P. Gygi,Robin Reed +6 more
TL;DR: The data indicate that the RNAP II/U1 snRNP machinery functions in a wide variety of molecular pathways, and these pathways are candidates for playing roles in ALS/SMA pathogenesis.
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Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteins.
Kimberly Anderson,Kyle A. Nordquist,Xianlong Gao,Kristin C. Hicks,Bo Zhai,Steven P. Gygi,Tarun B. Patel +6 more
TL;DR: It is demonstrated that silencing and expression of prolyl hydroxylase domain proteins (PHD1–3) increase and decrease, respectively, the cellular content of Spry2 and provide a novel mechanism of regulating growth factor signaling.
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Selenoprotein S is involved in maintenance and transport of multiprotein complexes.
Anton A. Turanov,Valentina A. Shchedrina,Robert A. Everley,Alexei V. Lobanov,Sun Hee Yim,Stefano M. Marino,Steven P. Gygi,Dolph L. Hatfield,Vadim N. Gladyshev +8 more
TL;DR: A large-scale affinity isolation of human SelS and its mutant forms and the proteins that interact with them suggest that SelS participates in intracellular membrane transport and maintenance of protein complexes by anchoring them to the ER membrane.
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Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts
Jae-Hyuck Shim,Matthew B. Greenblatt,Weiguo Zou,Zhiwei Huang,Marc N. Wein,Nicholas J. Brady,Dorothy Hu,Jean Charron,Heather R. Brodkin,Gregory A. Petsko,Dennis M. Zaller,Bo Zhai,Steven P. Gygi,Laurie H. Glimcher,Dallas C. Jones +14 more
TL;DR: SHN3 is identified as a dampener of ERK activity that functions in part downstream of WNT signaling in osteoblasts that holds promise as a therapy for osteoporosis.
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Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes.
Shangyu Hong,Wei Song,Peter-James H. Zushin,Bingyang Liu,Mark P. Jedrychowski,Amir I. Mina,Zhaoming Deng,Dimitrije Cabarkapa,Jessica A. Hall,Colin J. Palmer,Hassan Aliakbarian,John Szpyt,Steven P. Gygi,Ali Tavakkoli,Lydia Lynch,Norbert Perrimon,Alexander S. Banks +16 more
TL;DR: It is suggested that ERK activation in adipocytes and subsequent phosphorylation of the β3AR on S247 are critical regulatory steps in the enhanced adipocyte lipolysis of obesity.