S
Steven P. Gygi
Researcher at Harvard University
Publications - 778
Citations - 147003
Steven P. Gygi is an academic researcher from Harvard University. The author has contributed to research in topics: Proteome & Phosphorylation. The author has an hindex of 172, co-authored 704 publications receiving 129173 citations. Previous affiliations of Steven P. Gygi include University of Rochester Medical Center & Cell Signaling Technology.
Papers
More filters
Journal ArticleDOI
Cdc2-like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis through Disruption of the PGC-1α and MED1 Complex
Mitsuhisa Tabata,Joseph T. Rodgers,Jessica A. Hall,Yoonjin Lee,Mark P. Jedrychowski,Steven P. Gygi,Pere Puigserver +6 more
TL;DR: It is shown that Cdc2-like kinase 2 (Clk2) suppresses fatty acid oxidation and ketone body production during diet-induced obesity, and it is suggested that inhibition of hepatic Clk2 could provide new therapies in the treatment of fatty liver disease.
Journal ArticleDOI
The cyclin D1-CDK4 oncogenic interactome enables identification of potential novel oncogenes and clinical prognosis.
Siwanon Jirawatnotai,Samanta Sharma,Wojciech Michowski,Bhoom Suktitipat,Yan Geng,John Quackenbush,Joshua E. Elias,Steven P. Gygi,Yaoyu E. Wang,Piotr Sicinski +9 more
TL;DR: These studies illustrate the utility of analyzing the interactomes of proteins involved in cancer to uncover potential oncogenes, or to allow better cancer prognosis, as well as derived an Aggregate Expression Score (AES), which quantifies the expression of all cyclin D1 interactors in a given tumor.
Journal ArticleDOI
SUMOylation of pancreatic glucokinase regulates its cellular stability and activity
Ingvild Aukrust,Lise Bjørkhaug,Lise Bjørkhaug,Maria Negahdar,Janne Molnes,Janne Molnes,Bente B. Johansson,Yvonne Müller,Yvonne Müller,Wilhelm Haas,Steven P. Gygi,Oddmund Søvik,Torgeir Flatmark,Rohit N. Kulkarni,Pål R. Njølstad +14 more
TL;DR: The pancreatic isoform of human glucokinase is SUMOylated in vitro, using recombinant enzymes, and in insulin-secreting model cells, showing a novel form of modification, regulating its cellular stability and activity.
Journal ArticleDOI
Incorporation of Drugs for the Treatment of Substance Abuse into Pigmented and Nonpigmented Hair
TL;DR: It is demonstrated that L-alpha-acetylmethadol, methadone, buprenorphine, and metabolites are distributed into hair in a dose-related manner with a preference for pigmented hair.