S
Steven R. Smith
Researcher at Pennington Biomedical Research Center
Publications - 168
Citations - 13187
Steven R. Smith is an academic researcher from Pennington Biomedical Research Center. The author has contributed to research in topics: Adipose tissue & Insulin resistance. The author has an hindex of 53, co-authored 163 publications receiving 12049 citations. Previous affiliations of Steven R. Smith include National Institutes of Health & Palo Alto University.
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Journal ArticleDOI
The Human Serum Metabolome
Nikolaos Psychogios,David Hau,Jun Peng,An Chi Guo,Rupasri Mandal,Souhaila Bouatra,Igor Sinelnikov,Ramanarayan Krishnamurthy,Roman Eisner,Bijaya Gautam,Nelson Young,Jianguo Xia,Craig Knox,Edison Dong,Paul Huang,Zsuzsanna Hollander,Theresa L. Pedersen,Steven R. Smith,Fiona Bamforth,Russell Greiner,Bruce M. McManus,John W. Newman,Theodore L. Goodfriend,David S. Wishart,David S. Wishart +24 more
TL;DR: This work has combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today's technology) in the human serum metabolome.
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Reduced Adipose Tissue Oxygenation in Human Obesity: Evidence for Rarefaction, Macrophage Chemotaxis, and Inflammation Without an Angiogenic Response
Magdalena Pasarica,Olga Sereda,Leanne M. Redman,Diana C. Albarado,David Hymel,Laura E. Roan,Jennifer Rood,David H. Burk,Steven R. Smith +8 more
TL;DR: Adipose tissue rarefaction might lie upstream of both low AT pO2 and inflammation in obesity, and novel approaches to treat the dysfunctional AT found in obesity are suggested.
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A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle
Lauren M. Sparks,Hui Xie,Robert A. Koza,Randall L. Mynatt,Matthew W. Hulver,George A. Bray,Steven R. Smith +6 more
TL;DR: Results suggest a mechanism whereby HFD downregulates genes necessary for OXPHOS and mitochondrial biogenesis and, if sustained, may result in mitochondrial dysfunction in the prediabetic/insulin-resistant state.
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The relationship of waist circumference and BMI to visceral, subcutaneous, and total body fat: sex and race differences.
Sarah M. Camhi,George A. Bray,Claude Bouchard,Frank L. Greenway,William D. Johnson,Robert L. Newton,Eric Ravussin,Donna H. Ryan,Steven R. Smith,Peter T. Katzmarzyk +9 more
TL;DR: Sex differences, and in some instances race differences, in the relationships between anthropometry and fat‐specific depots demonstrate that these characteristics need to be considered when predicting adiposity from WC or BMI.
Journal ArticleDOI
Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus.
Eric Ravussin,Steven R. Smith +1 more
TL;DR: Two new paradigms have emerged that may explain the established links between adiposity and disease and provide a framework to advance the understanding of the pathophysiology of the insulin‐resistance syndrome.