S
Stuart T. Nichol
Researcher at Centers for Disease Control and Prevention
Publications - 395
Citations - 37968
Stuart T. Nichol is an academic researcher from Centers for Disease Control and Prevention. The author has contributed to research in topics: Virus & Ebola virus. The author has an hindex of 100, co-authored 388 publications receiving 34457 citations. Previous affiliations of Stuart T. Nichol include Institute of Tropical Medicine Antwerp & National Center for Immunization and Respiratory Diseases.
Papers
More filters
Journal ArticleDOI
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
Martin J. Vincent,Eric Bergeron,Suzanne Benjannet,Bobbie R. Erickson,Pierre E. Rollin,Thomas G. Ksiazek,Nabil G. Seidah,Stuart T. Nichol +7 more
TL;DR: Chloroquine is effective in preventing the spread of SARS CoV in cell culture and the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.
Journal ArticleDOI
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Travis K. Warren,Robert Jordan,Michael K. Lo,Adrian S. Ray,Richard L. Mackman,Veronica Soloveva,Dustin Siegel,Michel Perron,Roy Bannister,Hui Hon Chung,Nate Larson,Robert G. Strickley,Jay Wells,Kelly S. Stuthman,Sean A. Van Tongeren,Nicole L. Garza,Ginger Donnelly,Amy C. Shurtleff,Cary Retterer,Dima N. Gharaibeh,Rouzbeh Zamani,Tara Kenny,Brett P. Eaton,Elizabeth C. Grimes,Lisa S. Welch,Laura Gomba,Catherine L. Wilhelmsen,Donald K. Nichols,Jonathan E. Nuss,Elyse R. Nagle,Jeffrey R. Kugelman,Gustavo Palacios,Edward Doerffler,Sean Neville,Ernest Carra,Michael O. Clarke,Lijun Zhang,Willard Lew,Bruce Ross,Queenie Wang,Kwon Soo Chun,Lydia Wolfe,Darius Babusis,Yeojin Park,Kirsten M. Stray,Iva Trancheva,Joy Y. Feng,Ona Barauskas,Yili Xu,Pamela Wong,Molly R. Braun,Mike Flint,Laura K. McMullan,Shan Shan Chen,Rachel Fearns,S. Swaminathan,Douglas L. Mayers,Christina F. Spiropoulou,William A. Lee,Stuart T. Nichol,Tomas Cihlar,Sina Bavari +61 more
TL;DR: These results show the first substantive post-exposure protection by a small-molecule antiviral compound against EBOV in nonhuman primates, and the broad-spectrum antiviral activity of GS-5734 in vitro against other pathogenic RNA viruses, including filoviruses, arenavirus, and coronavirus suggests the potential for wider medical use.
Journal ArticleDOI
Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness
Stuart T. Nichol,Christina F. Spiropoulou,Sergey P. Morzunov,Pierre E. Rollin,Thomas G. Ksiazek,Heinz Feldmann,Anthony Sanchez,James E. Childs,Sherif R. Zaki,Clarence J. Peters +9 more
TL;DR: A mysterious respiratory illness with high mortality was recently reported in the southwestern United States and nucleotide sequence analysis revealed the associated virus to be a new hantavirus and provided a direct genetic link between infection in patients and rodents.
Journal ArticleDOI
Hantavirus Pulmonary Syndrome: A Clinical Description of 17 Patients with a Newly Recognized Disease
Jeffrey S. Duchin,Frederick Koster,Clarence J. Peters,Gary L. Simpson,Gary L. Simpson,Bruce Tempest,Sherif R. Zaki,Thomas G. Ksiazek,Pierre E. Rollin,Stuart T. Nichol,Edith T. Umland,Ronald L. Moolenaar,Susan E. Reef,Kurt B. Nolte,Margaret M. Gallaher,Jay C. Butler,Robert F. Breiman +16 more
TL;DR: Clinical, laboratory, and autopsy data on the first 17 persons with confirmed infection from this newly recognized strain of hantavirus identified as the cause of an outbreak of severe respiratory illness in the southwestern United States are analyzed.
Journal Article
Hantavirus Pulmonary Syndrome: Pathogenesis of an Emerging Infectious Disease
Sherif R. Zaki,Patricia W. Greer,L M Coffield,Cynthia S. Goldsmith,Kurt B. Nolte,Kathy Foucar,Richard M. Feddersen,Ross E. Zumwalt,Gayle L. Miller,Ali S. Khan,Pierre E. Rollin,Thomas G. Ksiazek,Stuart T. Nichol,Brian W. J. Mahy,Clarence J. Peters +14 more
TL;DR: Pulmonary histopathological features were similar in most of the fatal HPS cases and consisted of an interstitial pneumonitis with a variable mononuclear cell infiltrate, edema, and focal hyaline membranes, however, pulmonary features were significantly different and included diffuse alveolar damage and variable degrees of severe air space disorganization.