Author
Subhajit Maity
Other affiliations: Ramakrishna Mission Vivekananda Centenary College
Bio: Subhajit Maity is an academic researcher from University of Calcutta. The author has contributed to research in topics: Naringenin & Quercetin. The author has an hindex of 7, co-authored 11 publications receiving 263 citations. Previous affiliations of Subhajit Maity include Ramakrishna Mission Vivekananda Centenary College.
Papers
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TL;DR: Histopathology and several blood parameters indicated that oral administrations of nanoparticles were free from toxicity and suggested that polymeric formulations were quite effective for oral delivery of the flavonoid as a therapeutic agent in the treatment of dyslipidemia, hyperglycemia and haemoglobin iron-mediated oxidative stress in type 1 diabetic model.
144 citations
TL;DR: A pronounced hypoglycaemic effect and efficient maintenance of glucose homeostasis was evident in diabetic rat after peroral delivery of these quercetin nanoparticles in comparison to free oral quercets, suggesting the fabrication of an efficient carrier of oral quERCetin for diabetes treatment.
123 citations
TL;DR: MG-derived AGEs may have an important role as the precursors of protein aggregation, which, in turn, may be associated with physiological complications.
41 citations
TL;DR: How apoptotic pathways differentially regulate copper induced immunosuppression is demonstrated and the role of other partially responsible apoptotic molecules like p27, p73, p62, poly (ADP-ribose) polymerase (PARP) that differentially changed due to copper treatment in spleen and thymus of Swiss albino mice are identified.
37 citations
TL;DR: Two cost effective polymers, sodium alginate and a modified chitosan derivative (succinyl chitOSan) were used for encapsulating quercetin through ionic crosslinking and showed pH sensitive and self-sustained release of encapsulated quercets, protecting it from the harsh environment and enzymatic deactivation in the gastrointestinal tract.
Abstract: This study aims at the development of efficient, biocompatible, biodegradable and bio-safe polymeric carriers for investigating the pharmaceutical potentialities of bioflavonoid quercetin in antidiabetic research. In this article, two cost effective polymers, sodium alginate and a modified chitosan derivative (succinyl chitosan) were used for encapsulating quercetin through ionic crosslinking. In vitro biophysical characterizations like Fourier Transforms Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), swelling index, drug entrapment and loading efficiency were investigated. The prepared micro-formulations could efficiently encapsulate 94% quercetin and showed pH sensitive and self-sustained release of encapsulated quercetin, protecting it from the harsh environment and enzymatic deactivation in the gastrointestinal tract. An in vivo pharmacological study revealed a pronounced hypoglycemia effect in a diabetic rat model after peroral delivery of the quercetin microparticles in comparison to free quercetin. No acute systemic toxicity is evident following its oral administration in rats, ensuring it as an efficient carrier for oral quercetin carrier system in animal models.
25 citations
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TL;DR: Chitosan-based NP have various applications in non-parenteral drug delivery for the treatment of cancer, gastrointestinal diseases, pulmonary diseases, drug delivery to the brain and ocular infections which will be exemplified in this review.
Abstract: The focus of this review is to provide an overview of the chitosan based nanoparticles for various non-parenteral applications and also to put a spotlight on current research including sustained release and mucoadhesive chitosan dosage forms. Chitosan is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound dressing applications. Chitosan has been used as a carrier in polymeric nanoparticles for drug delivery through various routes of administration. Chitosan has chemical functional groups that can be modified to achieve specific goals, making it a polymer with a tremendous range of potential applications. Nanoparticles (NP) prepared with chitosan and chitosan derivatives typically possess a positive surface charge and mucoadhesive properties such that can adhere to mucus membranes and release the drug payload in a sustained release manner. Chitosan-based NP have various applications in non-parenteral drug delivery for the treatment of cancer, gastrointestinal diseases, pulmonary diseases, drug delivery to the brain and ocular infections which will be exemplified in this review. Chitosan shows low toxicity both in vitro and some in vivo models. This review explores recent research on chitosan based NP for non-parenteral drug delivery, chitosan properties, modification, toxicity, pharmacokinetics and preclinical studies.
771 citations
TL;DR: Catechins showed the highest ABTS-scavenging capacity, the highest stoichiometry of Fe3+ reduction in the FRAP assay and belonged to the most efficient compounds in protection against SIN-1 induced oxidation of dihydrorhodamine 123, AAPH-induced fluorescein bleaching and hypochlorite-inducedfluoresce in bleaching.
269 citations
TL;DR: In this paper, the use of polymeric nanoparticles as drug delivery systems of anticancer compounds, their physico-chemical properties and their ability to be efficiently localized in specific tumor tissues have been described.
Abstract: Advances in nanotechnology have favored the development of novel colloidal formulations able to modulate the pharmacological and biopharmaceutical properties of drugs. The peculiar physico-chemical and technological properties of nanomaterial-based therapeutics have allowed for several successful applications in the treatment of cancer. The size, shape, charge and patterning of nanoscale therapeutic molecules are parameters that need to be investigated and modulated in order to promote and optimize cell and tissue interaction. In this review, the use of polymeric nanoparticles as drug delivery systems of anticancer compounds, their physico-chemical properties and their ability to be efficiently localized in specific tumor tissues have been described. The nanoencapsulation of antitumor active compounds in polymeric systems is a promising approach to improve the efficacy of various tumor treatments.
169 citations
TL;DR: Mechanisms by which hyperhomocysteinemia affects cellular proteostasis are described, a comprehensive account of the biological chemistry of homocysteine-containing proteins is provided, and pathophysiological consequences and clinical implications of their formation are discussed.
Abstract: Epidemiological studies established that elevated homocysteine, an important intermediate in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including heart and brai...
147 citations
TL;DR: A pronounced hypoglycaemic effect and efficient maintenance of glucose homeostasis was evident in diabetic rat after peroral delivery of these quercetin nanoparticles in comparison to free oral quercets, suggesting the fabrication of an efficient carrier of oral quERCetin for diabetes treatment.
123 citations