Suman Chowdhury

TL;DR: The present study demonstrated the binding potential of approximately 50 phytochemicals with Nsp15 and capable of inhibiting the viral replication, although in vitro and in vivo tests are required to confirm these findings.

TL;DR: Benperidol was found to be the best candidate drug interacting with different target proteins involved in AD and led to unravel the potential of leading antipsychotic drugs such as pimozide, bromaridol, melperone, anisoperidone, ben peridol and anisopirol against multiple targets associated with AD.

TL;DR: In this article, the therapeutic potential of alpha-terpinyl acetate as it binds to multiple drug targets, resulting in inhibition of acetylcholinesterase (AChE) enzyme, butyrylcholine choline (BuChE), reduced Aβ induced neurotoxicity, reduced hydrogen peroxide induced oxidative stress, antioxidant capacity, and anti-amyloidogenic property.

TL;DR: An aqueous extract of Cumin cyminum was tested for in vitro acetylcholinesterase inhibitory activity based on Ellman’s method and the mode of AChE inhibition was elucidated by kinetic studies.

TL;DR: In this paper, the authors evaluated the effect of piperine on Alzheimer's disease in diabetic rats and showed that piperines not only improved memory but also reduced the expression of specific AD-related genes.