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Sumit Mukherjee

Bio: Sumit Mukherjee is an academic researcher from National Institute of Technology, Rourkela. The author has contributed to research in topics: Drosophila (subgenus) & Nanomaterials. The author has an hindex of 5, co-authored 12 publications receiving 300 citations.

Papers
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Journal ArticleDOI
TL;DR: Graphene- and graphene oxide-based nanomaterials have gained broad interests in research because of their unique physiochemical properties and their substantial use in medicine and biology.
Abstract: Graphene- and graphene oxide-based nanomaterials have gained broad interests in research because of their unique physiochemical properties. The 2D allotropic structure allows it to be used in various biological fields. The biomedical applications of graphene and its composite include its use in gene and small molecular drug delivery. It is further used for biofunctionalization of protein, in anticancer therapy, as an antimicrobial agent for bone and teeth implantation. The biocompatibility of the newly synthesized nanomaterials allows its substantial use in medicine and biology. The current review summarizes the chemical structure and biological application of graphene in various fields.

326 citations

Journal ArticleDOI
TL;DR: This review summarises the use of various widely used nanoparticle in the field of dentistry, including nanoparticles used for oral disease preventive drugs, prostheses and for teeth implantation.
Abstract: Nanotechnology is widely used in our day to day life including its use in medicine. Using nanotechnology, it is easy to analyze and manipulate atoms, chemical bonds and molecules present between various compounds. Nanotechnology is used in the dental field as nano dentistry. While choosing the nanoparticle for the use in the field of nano dentistry its chemical, physical, along with the biological aspect of nanostructures are taken into account. Often various atoms or molecules are added to form the functional structure. Nanostructures are used in innovations or diagnosis of dentistry. Some nanoparticles are used for oral disease preventive drugs, prostheses and for teeth implantation. Nanomaterials further deliver oral fluid or drugs, preventing and curing some oral disease (oral cancer) and maintain oral health care up to a high extent. This review summarises the use of various widely used nanoparticle in the field of dentistry.

180 citations

Journal ArticleDOI
TL;DR: For the first time, oral administration of GO is found which acts as a mutagen and causes various behavioral and developmental defects in the offspring of Drosophila melanogaster.
Abstract: The current study checks the effect of various concentrations of dietary graphene oxide (GO) nano-sheets on the development of Drosophila melanogaster. GO was synthesized and characterized by XRD, FTIR, FESEM, and TEM analytical techniques. Various concentrations of GO were mixed with the fly food and flies were transferred to the vial. Various behavioral and morphological as well as genetic defects were checked on the different developmental stages of the offspring. In the larval stage of development, the crawling speed and trailing path change significantly than the control. GO induces the generation of oxygen radicals within the larval hemolymph as evidenced by nitroblue tetrazolium assay. GO induces DNA damage within the gut cell, which was detected by Hoechst staining and within hemolymph by comet assay. Adult flies hatched after GO treatment show defective phototaxis and geotaxis behavior. Besides behavior, phenotypic defects were observed in the wing, eye, thorax bristles, and mouth parts. At 300 mg/L concentration, wing spots were observed. Altogether, the current study finds oral administration of GO which acts as a mutagen and causes various behavioral and developmental defects in the offspring. Here for the first time, we are reporting GO, which acts as a teratogen in Drosophila, besides its extensive medical applications.

32 citations

Journal ArticleDOI
13 Aug 2019
TL;DR: Results suggest that cellulose nanofibres have no significant cytotoxic effects on Drosophila, and developmental and behavioural abnormalities suggest that CNF may act as a behavioural teratogen.
Abstract: Wood-based cellulose nanofibrils (CNF) offer an excellent scaffold for drug-delivery formulation development. However, toxicity and haemocompatibility of the drug carrier is always an important issue. In this study, toxicity-related issues of CNF were addressed. Different doses of CNF were orally administered to Drosophila and different tests like the developmental cycle, trypan blue exclusion assay, larva crawling assay, thermal sensitivity assay, cold sensitivity assay, larval light preference test, climbing behaviour, nitroblue tetrazolium (NBT) reduction assay, adult phenotype, and adult weight were conducted to observe the impact on its development and behaviour. A haemocompatibility assay was done on the blood taken from healthy Wistar rats. In Drosophila, the abnormalities in larval development and behaviour were observed in the behavioural assays. However, the cytotoxic effect could not be confirmed by the gut staining and level of reactive oxygen species. The larvae developed into an adult without any abnormality in the phenotype. The CNF did cause loss of weight in the adult flies and did not cause much toxicity within the body since there was no phenotypic defect. Hemolysis data also suggested that CNF was safe at lower doses, as the data was well within acceptable limits. All these results suggest that cellulose nanofibres have no significant cytotoxic effects on Drosophila. However, the developmental and behavioural abnormalities suggest that CNF may act as a behavioural teratogen.

24 citations

Journal ArticleDOI
TL;DR: GGNCs are suggested as a non-genotoxic nanoparticle for various biological applications and a significant reduction in body weight was found in adult flies which is further correlated with variation of protein, carbohydrate, triglyceride, and antioxidant enzymes.

13 citations


Cited by
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Journal ArticleDOI
TL;DR: This review focused on the latest data regarding the biomedical use of AgNP-based nanostructures, including aspects related to their potential toxicity, unique physiochemical properties, and biofunctional behaviors, discussing herein the intrinsic anti-inflammatory, antibacterial, antiviral, and antifungal activities of silver-based Nanostructure.
Abstract: During the past few years, silver nanoparticles (AgNPs) became one of the most investigated and explored nanotechnology-derived nanostructures, given the fact that nanosilver-based materials proved to have interesting, challenging, and promising characteristics suitable for various biomedical applications. Among modern biomedical potential of AgNPs, tremendous interest is oriented toward the therapeutically enhanced personalized healthcare practice. AgNPs proved to have genuine features and impressive potential for the development of novel antimicrobial agents, drug-delivery formulations, detection and diagnosis platforms, biomaterial and medical device coatings, tissue restoration and regeneration materials, complex healthcare condition strategies, and performance-enhanced therapeutic alternatives. Given the impressive biomedical-related potential applications of AgNPs, impressive efforts were undertaken on understanding the intricate mechanisms of their biological interactions and possible toxic effects. Within this review, we focused on the latest data regarding the biomedical use of AgNP-based nanostructures, including aspects related to their potential toxicity, unique physiochemical properties, and biofunctional behaviors, discussing herein the intrinsic anti-inflammatory, antibacterial, antiviral, and antifungal activities of silver-based nanostructures.

773 citations

Journal ArticleDOI
01 Jan 2020-Land
TL;DR: In this paper, the impact of various agrochemicals on the soil microbial diversity and environment is reviewed, and the importance of smallholder farmers for sustainable crop protection and enhancement solutions is highlighted.
Abstract: The World Health Organization (WHO) states that in developing nations, there are three million cases of agrochemical poisoning. The prolonged intensive and indiscriminate use of agrochemicals adversely affected the soil biodiversity, agricultural sustainability, and food safety, bringing in long-term harmful effects on nutritional security, human and animal health. Most of the agrochemicals negatively affect soil microbial functions and biochemical processes. The alteration in diversity and composition of the beneficial microbial community can be unfavorable to plant growth and development either by reducing nutrient availability or by increasing disease incidence. Currently, there is a need for qualitative, innovative, and demand-driven research in soil science, especially in developing countries for facilitating of high-quality eco-friendly research by creating a conducive and trustworthy work atmosphere, thereby rewarding productivity and merits. Hence, we reviewed (1) the impact of various agrochemicals on the soil microbial diversity and environment; (2) the importance of smallholder farmers for sustainable crop protection and enhancement solutions, and (3) management strategies that serve the scientific community, policymakers, and land managers in integrating soil enhancement and sustainability practices in smallholder farming households. The current review provides an improved understanding of agricultural soil management for food and nutritional security.

341 citations

01 Jan 2017
TL;DR: In this article, it was shown that GO does not need linking molecules in order to be deposited onto the surface of the electrodes, since it attaches spontaneously and keeps its electrochemical properties.
Abstract: Popularity of graphene oxide (GO) became ballistic in the last few years – in short, it almost seems that now everyone wants to work with graphene. However, as the number of electrochemical papers about graphene grows, so is the amount of misinterpretations. Our work was mostly focused on preparation of GO and its electrochemical properties, namely catalysis. Our results show, that chemical preparation of GO by strong oxidation is very tricky. Several approaches were tested, such as different sizes of graphite particles, oxidation mixtures, even repetitive preparations under the same conditions usually resulted in different products. Another big topic are impurities which are present due to natural occurrence in graphite and some of them might be also introduced during purification processes of GO. This could also lead to often observed catalytic activity of graphene. From our observations neither selectivity nor significant electrocatalytic abilities of the reduced graphene oxide modified electrodes towards H2O2 were observed. Moreover, our results suggest that GO does not need linking molecules in order to be deposited onto the surface of the electrodes, since it attaches spontaneously and keeps its electrochemical properties. Graphene is usually reported as a superior material, but its proper description and characterization should not be underestimated.

227 citations

Journal Article
TL;DR: In this paper, Jiang et al. proposed a method to solve the problem of high magnetic field field (HGF) with the use of a magnetometer and showed that the proposed method can achieve state-of-the-art performance.
Abstract: Z. Jiang, 2, ∗ Y. Zhang, H. L. Stormer, 3, 4 and P. Kim Department of Physics, Columbia University, New York, New York 10027, USA National High Magnetic Field Laboratory, Tallahassee, Florida 32310, USA Department of Applied Physics and Applied Mathematics, Columbia University, New York, New York 10027, USA Bell Laboratories, Alcatel-Lucent, Murray Hill, New Jersey 07974, USA (Dated: February 1, 2008)

225 citations

Journal ArticleDOI
TL;DR: Modified zirconia surfaces clearly demonstrate faster osseointegration than that on untreated surfaces, however, there is no consensus regarding the surface treatment and consequent morphological aspects of the surfaces to enhance osseointedegration.

153 citations