Author
Sun-Woong Kang
Other affiliations: Hanyang University, University of Science and Technology, University of Utah
Bio: Sun-Woong Kang is an academic researcher from Korea University of Science and Technology. The author has contributed to research in topics: Transplantation & PLGA. The author has an hindex of 37, co-authored 103 publications receiving 4237 citations. Previous affiliations of Sun-Woong Kang include Hanyang University & University of Science and Technology.
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TL;DR: Results demonstrate that the HP-PLGA delivery system is capable of potentiating the osteogenic efficacy of BMP-2, and underscore its importance as a possible bone regeneration strategy.
263 citations
TL;DR: The scaffolds applied in this study were found to exhibit excellent tissue compatibility to SMCs and might be very useful for vascular tissue engineering.
236 citations
TL;DR: A haemostatic hypodermic needle able to prevent bleeding following tissue puncture is presented, coated with partially crosslinked catechol-functionalized chitosan that undergoes a solid-to-gel phase transition in situ to seal punctured tissues.
Abstract: The penetration of tissues with syringe needles is a common clinical practice that inevitably results in blood loss at the puncture site. This blood loss can now be eliminated using self-sealing haemostatic needles.
206 citations
TL;DR: It is demonstrated that hESC-EC transplantation improves blood perfusion and limb salvage by facilitating postnatal neovascularization in a mouse model of hindlimb ischemia and might be useful as an alternative cell source for angiogenic therapy.
Abstract: Background— We established an efficient preparation method to obtain endothelial-like cells (ECs) from human embryonic stem cells (hESCs) and tested whether these hESC-ECs would show therapeutic po...
199 citations
TL;DR: This study shows that a bFGF delivery system using HCPNs in fibrin gel exhibits controllable, long-term, zero-order release ofbFGF and potentiates the angiogenic efficacy of bF GF administration.
190 citations
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TL;DR: This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.
5,372 citations
TL;DR: Polycaprolactone (PCL) was used in the biomaterials field and a number of drug-delivery devices for up to 3-4 years.
3,070 citations
TL;DR: The ability of pore size and porosity of scaffolds to direct cellular responses and alter the mechanical properties of scaffold will be reviewed, followed by a look at nature's own scaffold, the extracellular matrix.
Abstract: Tissue engineering applications commonly encompass the use of three-dimensional (3D) scaffolds to provide a suitable microenvironment for the incorporation of cells or growth factors to regenerate ...
2,075 citations
TL;DR: Micro-CT images of bone-like constructs that result from transplantation of osteoblasts on gels that degrade over a time frame of several months leading to improved bone formation are presented.
Abstract: [Image: see text] Alginate hydrogels are proving to have a wide applicability as biomaterials. They have been used as scaffolds for tissue engineering, as delivery vehicles for drugs, and as model extracellular matrices for basic biological studies. These applications require tight control of a number of material properties including mechanical stiffness, swelling, degradation, cell attachment, and binding or release of bioactive molecules. Control over these properties can be achieved by chemical or physical modifications of the polysaccharide itself or the gels formed from alginate. The utility of these modified alginate gels as biomaterials has been demonstrated in a number of in vitro and in vivo studies.Micro-CT images of bone-like constructs that result from transplantation of osteoblasts on gels that degrade over a time frame of several months leading to improved bone formation.
1,579 citations
TL;DR: The objective of this article is to review the fundamentals and recent advances in hydrogel network design as well as mathematical modeling approaches related to controlled molecule release from hydrogels.
1,515 citations