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Sung Won Ko

Bio: Sung Won Ko is an academic researcher from Chonbuk National University. The author has contributed to research in topics: Nanofiber & Biocompatibility. The author has an hindex of 10, co-authored 16 publications receiving 334 citations.

Papers
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Journal ArticleDOI
TL;DR: The results suggested that the optimized 20wt% of chitosan supplemented hybrid electrospun fibrous scaffold has significant effect in biomedical field to create osteogenic capabilities for tissue engineering.

87 citations

Journal ArticleDOI
01 Sep 2018-Carbon
TL;DR: A self-electrical stimulated double-layered nerve guidance conduit assembled from electrospun mats with an aligned oriented inward layer covered with a random oriented outer layer that maintains a strong adaptability in axonal regeneration is engineered.

80 citations

Journal ArticleDOI
TL;DR: The novel as-prepared multifunctional electrospun fibrous scaffold could suggest new avenues for exploration as promising osteoproductive and osteoinductive biomaterials that offer great benefit to bone tissue engineering.

69 citations

Journal ArticleDOI
TL;DR: Heterogeneous scaffolds from a blend of PCL with polyethylene glycol that is composed of nano-nets along with backbone/main fibers are proposed via an electro-spinning/netting (ESN) technique and revealed that the heterogeneous fibrous membrane could be useful in the design and tailoring of a suitable structure as a scaffold for bone tissue engineering.

50 citations

Journal ArticleDOI
TL;DR: A design and fabricate multifunctional localized platform for cancer therapy utilizing pH and NIR dual responsive property from PDA alone in a fibrous mat is presented, a major step forward towards a therapeutic model to cancer treatment.
Abstract: We report a design and fabricate multifunctional localized platform for cancer therapy. Multiple stimuli-responsive polydopamine (PDA) was used for surface modification of electrospun doxorubicin hydrochloride (DOX) loaded polycaprolactone (PCL) fibers to make a designated platform. Photothermal properties such as photothermal performance and stability of the resulting composite mats were studied under the irradiation of the near-infrared (NIR) laser of 808 nm. With the incorporation of PDA into the fiber, a remarkable increase of local temperature was recorded under NIR illumination in a concentration-dependent manner with excellent stability. Drug released assay results revealed PDA coated PCL-DOX mats showed pH and NIR dual responsive behavior thereby exhibiting improved drug release in an acidic medium compared to physiological pH condition (pH 7.4) which is further increased by NIR exposure. The cancer activity in vitro of the mats was evaluated using cell counting (CCK) and live and dead cell assays. The combined effect of NIR mediated hyperthermia and chemo release resulting improved cells death has been reported. In summary, this study presents a major step forward towards a therapeutic model to cancer treatment utilizing pH and NIR dual responsive property from PDA alone in a fibrous mat.

39 citations


Cited by
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01 Jan 1999
TL;DR: Caspases, a family of cysteine-dependent aspartate-directed proteases, are prominent among the death proteases as discussed by the authors, and they play critical roles in initiation and execution of this process.
Abstract: ■ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death that can be triggered by a variety of physiological and pathological stimuli. Studies performed over the past 10 years have demonstrated that proteases play critical roles in initiation and execution of this process. The caspases, a family of cysteine-dependent aspartate-directed proteases, are prominent among the death proteases. Caspases are synthesized as relatively inactive zymogens that become activated by scaffold-mediated transactivation or by cleavage via upstream proteases in an intracellular cascade. Regulation of caspase activation and activity occurs at several different levels: ( a) Zymogen gene transcription is regulated; ( b) antiapoptotic members of the Bcl-2 family and other cellular polypeptides block proximity-induced activation of certain procaspases; and ( c) certain cellular inhibitor of apoptosis proteins (cIAPs) can bind to and inhibit active caspases. Once activated, caspases cleave a variety of intracellular polypeptides, including major structural elements of the cytoplasm and nucleus, components of the DNA repair machinery, and a number of protein kinases. Collectively, these scissions disrupt survival pathways and disassemble important architectural components of the cell, contributing to the stereotypic morphological and biochemical changes that characterize apoptotic cell death.

2,685 citations

Journal ArticleDOI
TL;DR: A comprehensive summary of recent trends in development of single- (metal, ceramics and polymers), composite-type and cell-laden scaffolds that in addition to mechanical support, promote simultaneous tissue growth, and deliver different molecules or cells with therapeutic or facilitating regeneration effect is offered.

487 citations

Journal ArticleDOI
TL;DR: A comprehensive overview of the recent progress and potential developments of electrospun polymer matrices and their application as biomaterials is presented in this paper, where the authors present a comprehensive overview.

429 citations

Journal ArticleDOI
TL;DR: This comprehensive review provides chemistry, structures, advanced applications, and recent developments about nanocomposites obtained from biorenewable sources.
Abstract: Researchers have recently focused on the advancement of new materials from biorenewable and sustainable sources because of great concerns about the environment, waste accumulation and destruction, and the inevitable depletion of fossil resources. Biorenewable materials have been extensively used as a matrix or reinforcement in many applications. In the development of innovative methods and materials, composites offer important advantages because of their excellent properties such as ease of fabrication, higher mechanical properties, high thermal stability, and many more. Especially, nanocomposites (obtained by using biorenewable sources) have significant advantages when compared to conventional composites. Nanocomposites have been utilized in many applications including food, biomedical, electroanalysis, energy storage, wastewater treatment, automotive, etc. This comprehensive review provides chemistry, structures, advanced applications, and recent developments about nanocomposites obtained from biorenewable sources.

417 citations

Journal ArticleDOI
TL;DR: A review of a few polymeric nanocomposite biomaterials which are potential candidates for bone tissue regeneration, sculptured around a case by case basis of current research that is being undertaken in the field of bone regeneration engineering.

311 citations