S
Sungchul Hohng
Researcher at Seoul National University
Publications - 97
Citations - 6658
Sungchul Hohng is an academic researcher from Seoul National University. The author has contributed to research in topics: RNA & Argonaute. The author has an hindex of 31, co-authored 91 publications receiving 5801 citations. Previous affiliations of Sungchul Hohng include Howard Hughes Medical Institute & University of Illinois at Urbana–Champaign.
Papers
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Journal ArticleDOI
A practical guide to single-molecule FRET
TL;DR: A practical guide to using smFRET, focusing on the study of immobilized molecules that allow measurements of single-molecule reaction trajectories from 1 ms to many minutes, is provided.
Journal ArticleDOI
Near-complete suppression of quantum dot blinking in ambient conditions.
Sungchul Hohng,Taekjip Ha +1 more
TL;DR: It is shown that the quantum dot blinking can be suppressed with the emission duty cycle approaching 100% while maintaining biocompatibility.
Journal ArticleDOI
Functional Anatomy of the Human Microprocessor
Tuan Anh Nguyen,Myung Hyun Jo,Yeon Gil Choi,Joha Park,S. Chul Kwon,Sungchul Hohng,V. Narry Kim,Jae Sung Woo +7 more
TL;DR: This work reconstitutes human Microprocessor with purified recombinant proteins and finds that Microprocessor is an ∼364 kDa heterotrimeric complex of one DROSHA and two DGCR8 molecules, which allows for a general model for pri-miRNA processing.
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Single-molecule three-color FRET.
TL;DR: The single-molecule FRET technique is extended to three colors, using the DNA four-way (Holliday) junction as a model system that undergoes two-state conformational fluctuations and is able to show that the acceptor 1 arm moves away from the donor arm at the same time as theacceptor 2 arm approaches the donor hand, marking the first example of observing correlated movements of two different segments of a single molecule.
Journal ArticleDOI
Fluorescence-Force Spectroscopy Maps Two-Dimensional Reaction Landscape of the Holliday Junction
Sungchul Hohng,Sungchul Hohng,Sungchul Hohng,Ruobo Zhou,Michelle K. Nahas,Jin Yu,Klaus Schulten,David M.J. Lilley,Taekjip Ha,Taekjip Ha +9 more
TL;DR: In this article, a hybrid scheme combining force and fluorescence was developed to examine the effect of subpiconewton forces on the nanometer scale motion of the Holliday junction at 100-hertz bandwidth.