Sungho Hong

Bio: Sungho Hong is an academic researcher from Okinawa Institute of Science and Technology. The author has contributed to research in topics: Neural coding & Quantum chromodynamics. The author has an hindex of 17, co-authored 47 publications receiving 1264 citations. Previous affiliations of Sungho Hong include University of Washington & University of Pennsylvania.

GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time

Abstract: The mammalian suprachiasmatic nucleus (SCN) forms not only the master circadian clock but also a seasonal clock. This neural network of ∼10,000 circadian oscillators encodes season-dependent day-length changes through a largely unknown mechanism. We show that region-intrinsic changes in the SCN fine-tune the degree of network synchrony and reorganize the phase relationship among circadian oscillators to represent day length. We measure oscillations of the clock gene Bmal1, at single-cell and regional levels in cultured SCN explanted from animals raised under short or long days. Coupling estimation using the Kuramoto framework reveals that the network has couplings that can be both phase-attractive (synchronizing) and -repulsive (desynchronizing). The phase gap between the dorsal and ventral regions increases and the overall period of the SCN shortens with longer day length. We find that one of the underlying physiological mechanisms is the modulation of the intracellular chloride concentration, which can adjust the strength and polarity of the ionotropic GABAA-mediated synaptic input. We show that increasing day-length changes the pattern of chloride transporter expression, yielding more excitatory GABA synaptic input, and that blocking GABAA signaling or the chloride transporter disrupts the unique phase and period organization induced by the day length. We test the consequences of this tunable GABA coupling in the context of excitation–inhibition balance through detailed realistic modeling. These results indicate that the network encoding of seasonal time is controlled by modulation of intracellular chloride, which determines the phase relationship among and period difference between the dorsal and ventral SCN.

The choroid plexus is an important circadian clock component.

Abstract: Mammalian circadian clocks have a hierarchical organization, governed by the suprachiasmatic nucleus (SCN) in the hypothalamus. The brain itself contains multiple loci that maintain autonomous circadian rhythmicity, but the contribution of the non-SCN clocks to this hierarchy remains unclear. We examine circadian oscillations of clock gene expression in various brain loci and discovered that in mouse, robust, higher amplitude, relatively faster oscillations occur in the choroid plexus (CP) compared to the SCN. Our computational analysis and modeling show that the CP achieves these properties by synchronization of "twist" circadian oscillators via gap-junctional connections. Using an in vitro tissue coculture model and in vivo targeted deletion of the Bmal1 gene to silence the CP circadian clock, we demonstrate that the CP clock adjusts the SCN clock likely via circulation of cerebrospinal fluid, thus finely tuning behavioral circadian rhythms.

On the Couplings of Vector Mesons in AdS/QCD

Abstract: We address, in the AdS/CFT context, the issue of the universality of the couplings of the ρ meson to other hadrons. Exploring some models, we find that generically the ρ-dominance prediction fρgρHH = mρ2 does not hold, and that gρHH is not independent of the hadron H. However, we prove that, in any model within the AdS/QCD context, there are two limiting regimes where the gρHH, along with the couplings of all excited vector mesons as well, become H-independent: (1) when H is created by an operator of large dimension, and (2) when H is a highly-excited hadron. We also find a sector of a particular model where universality for the ρ coupling is exact. Still, in none of these cases need it be true that fρgρ = mρ2, although we find empirically that the relation does hold approximately (up to a factor of order two) within the models we have studied.

Quarkonium from the Fifth Dimension

Abstract: Adding fundamental matter of mass m_Q to N=4 Yang Mills theory, we study quarkonium, and "generalized quarkonium" containing light adjoint particles. At large 't Hooft coupling the states of spin<=1 are anomalously light (Kruczenski et al., hep-th/0304032). We examine their form factors, and show these hadrons are unlike any known in QCD. By a traditional yardstick they appear infinite in size (as with strings in flat space) but we show that this is a failure of the yardstick. All of the hadrons are actually of finite size ~ \sqrt{g^2N}/m_Q, regardless of their radial excitation level and of how many valence adjoint particles they contain. Certain form factors for spin-1 quarkonia vanish in the large-g^2N limit; thus these hadrons resemble neither the observed J/Psi quarkonium states nor rho mesons.

The geometry of biological time , by A. T. Winfree. Pp 544. DM68. Corrected Second Printing 1990. ISBN 3-540-52528-9 (Springer)

Abstract: 1980 Preface * 1999 Preface * 1999 Acknowledgements * Introduction * 1 Circular Logic * 2 Phase Singularities (Screwy Results of Circular Logic) * 3 The Rules of the Ring * 4 Ring Populations * 5 Getting Off the Ring * 6 Attracting Cycles and Isochrons * 7 Measuring the Trajectories of a Circadian Clock * 8 Populations of Attractor Cycle Oscillators * 9 Excitable Kinetics and Excitable Media * 10 The Varieties of Phaseless Experience: In Which the Geometrical Orderliness of Rhythmic Organization Breaks Down in Diverse Ways * 11 The Firefly Machine 12 Energy Metabolism in Cells * 13 The Malonic Acid Reagent ('Sodium Geometrate') * 14 Electrical Rhythmicity and Excitability in Cell Membranes * 15 The Aggregation of Slime Mold Amoebae * 16 Numerical Organizing Centers * 17 Electrical Singular Filaments in the Heart Wall * 18 Pattern Formation in the Fungi * 19 Circadian Rhythms in General * 20 The Circadian Clocks of Insect Eclosion * 21 The Flower of Kalanchoe * 22 The Cell Mitotic Cycle * 23 The Female Cycle * References * Index of Names * Index of Subjects

Low energy hadron physics in holographic QCD

Abstract: We present a holographic dual of four-dimensional, large N_c QCD with massless flavors. This model is constructed by placing N_f probe D8-branes into a D4 background, where supersymmetry is completely broken. The chiral symmetry breaking in QCD is manifested as a smooth interpolation of D8 - anti-D8 pairs in the supergravity background. The meson spectrum is examined by analyzing a five-dimensional Yang-Mills theory that originates from the non-Abelian DBI action of the probe D8-brane. It is found that our model yields massless pions, which are identified with Nambu-Goldstone bosons associated with the chiral symmetry breaking. We obtain the low-energy effective action of the pion field and show that it contains the usual kinetic term of the chiral Lagrangian and the Skyrme term. A brane configuration that defines a dynamical baryon is identified with the Skyrmion. We also derive the effective action including the lightest vector meson. Our model is closely related to that in the hidden local symmetry approach, and we obtain a Kawarabayashi-Suzuki-Riazuddin-Fayyazuddin-type relation among the couplings. Furthermore, we investigate the Chern-Simons term on the probe brane and show that it leads to the Wess-Zumino-Witten term. The mass of the \eta' meson is also considered, and we formulate a simple derivation of the \eta' mass term satisfying the Witten-Veneziano formula from supergravity.

QCD and a holographic model of hadrons

Abstract: We propose a five-dimensional framework for modeling low-energy properties of QCD. In the simplest three parameter model we compute masses, decay rates and couplings of the lightest mesons. The model fits experimental data to within 10%. The framework is a holographic version of the QCD sum rules, motivated by the anti-de Sitter/conformal field theory correspondence. The model naturally incorporates properties of QCD dictated by chiral symmetry, which we demonstrate by deriving the Gell-Mann-Oakes-Renner relationship for the pion mass.

Linear confinement and AdS/QCD

Abstract: In a theory with linear confinement, such as QCD, the masses squared m^2 of mesons with high spin S or high radial excitation number n are expected, from semiclassical arguments, to grow linearly with S and n. We show that this behavior can be reproduced within a putative 5-dimensional theory holographically dual to QCD (AdS/QCD). With the assumption that such a dual theory exists and describes highly excited mesons as well, we show that asymptotically linear m^2 spectrum translates into a strong constraint on the INFRARED behavior of that theory. In the simplest model which obeys such a constraint we find m^2 ~ (n+S).