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Sunil A Sheth

Researcher at University of Texas Health Science Center at Houston

Publications -  305
Citations -  7473

Sunil A Sheth is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 35, co-authored 197 publications receiving 5894 citations. Previous affiliations of Sunil A Sheth include University of California, Los Angeles & San Francisco VA Medical Center.

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A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

TL;DR: This work predicts 19 proteins to be important for the function of complex I (CI) of the electron transport chain and validate a subset of these predictions using RNAi, including C8orf38, which is shown to have an inherited mutation in a lethal, infantile CI deficiency.
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AST/ALT ratio predicts cirrhosis in patients with chronic hepatitis C virus infection.

TL;DR: The AST/ALT ratio is a dependable marker of fibrosis stage and cirrhosis in patients with chronic HCV infection.
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Systematic identification of human mitochondrial disease genes through integrative genomics.

TL;DR: By identifying candidate genes for eight mitochondrial disorders, this work expands the collection to 1,080 genes, which includes 368 novel predictions with a 10% estimated false prediction rate, and identifies mutations in MPV17 that result in hepatic mtDNA depletion syndrome.
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Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

TL;DR: The antiemetic meclizine pretreatment confers cardioprotection and neuroprotection against ischemia-reperfusion injury in murine models andNutrient-sensitized screening may provide a useful framework for understanding gene function and drug action within the context of energy metabolism.
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Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data

Bruce C.V. Campbell, +1296 more
- 01 Jan 2019 - 
TL;DR: Estimated ischaemic core volume was independently associated with functional independence and functional improvement but did not modify the treatment benefit of endovascular thrombectomy over standard medical therapy for improved functional outcome.