Showing papers by "Susan Lindquist published in 1987"
TL;DR: Electrophoretic analysis and Amino acid analysis suggest that the hypusine-containing protein is conserved among eukaryotes.
86 citations
TL;DR: Investigation of the relationship between the intracellular level and state of modification of the hypusine-containing protein and the rate and specificity of translation finds no correlation between the state of cellular translation and the persistence or reversal of this protein's modification.
24 citations
01 Jan 1987
TL;DR: Current knowledge of translational regulation in the heat-shock response of the fruit fly Drosophila melanogaster is reviewed, focusing on the response for two reasons: first, the response of Drosophile cells is the strongest known example of differential gene expression regulated at the translational level, and second, more is known about heat- shock protein synthesis in this organism than in any other.
Abstract: The heat-shock response has been the subject of intense investigation for several years The speed of the induction, the magnitude of the response, and the reproducibility of the effect combine to make it an ideal system for investigating mechanisms of gene expression in a wide variety of organisms In this chapter, I will review current knowledge of translational regulation in the response, focusing on the fruit fly Drosophila melanogaster for two reasons: First, the response of Drosophila cells is the strongest known example of differential gene expression regulated at the translational level Second, more is known about heat-shock protein synthesis in this organism than in any other
12 citations