S
Susan Lindquist
Researcher at Massachusetts Institute of Technology
Publications - 443
Citations - 86482
Susan Lindquist is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Heat shock protein & Saccharomyces cerevisiae. The author has an hindex of 147, co-authored 440 publications receiving 81067 citations. Previous affiliations of Susan Lindquist include University of Illinois at Chicago & Howard Hughes Medical Institute.
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Varying patterns of protein synthesis in Drosophila during heat shock: Implications for regulation
TL;DR: It now appears that the various heat-shock genes can be, to a rather considerable extent, regulated independently of one another and the patterns of protein synthesis in heat-shocked cells are regulated by mechanisms which act at several different levels of gene expression.
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Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation
Daniel F. Jarosz,Susan Lindquist +1 more
TL;DR: In this article, the authors find that the nature and adaptive value of Hsp90-contingent traits remain uncertain, but they find such traits to be both common and frequently adaptive.
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Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol.
Jiyan Ma,Susan Lindquist +1 more
TL;DR: It is reported that PrP retrogradely transported out of the endoplasmic reticulum produced both amorphous aggregates and a PrPSc-like conformation in the cytosol, and the distribution between these forms correlated with the rate of appearance in the Cytosol.
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A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures
TL;DR: The results indicate that native monomeric NM is composed of an ensemble of structures, having a collapsed and rapidly fluctuating N region juxtaposed with a more extended M region, which is likely to play a key role in prion conversion.
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Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish.
Nicolas Rohner,Daniel F. Jarosz,Johanna E. Kowalko,Masato Yoshizawa,William R. Jeffery,William R. Jeffery,Richard Borowsky,Susan Lindquist,Susan Lindquist,Clifford J. Tabin +9 more
TL;DR: It is suggested that cryptic variation played a role in the evolution of eye loss in cavefish and the first evidence for HSP90 as a capacitor for morphological evolution in a natural setting is provided.