S
Susan Lindquist
Researcher at Massachusetts Institute of Technology
Publications - 443
Citations - 86482
Susan Lindquist is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Heat shock protein & Saccharomyces cerevisiae. The author has an hindex of 147, co-authored 440 publications receiving 81067 citations. Previous affiliations of Susan Lindquist include University of Illinois at Chicago & Howard Hughes Medical Institute.
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Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.
TL;DR: It is reported that eliminating HSF1 protects mice from tumors induced by mutations of the RAS oncogene or a hot spot mutation in the tumor suppressor p53, and human cancer lines of diverse origins show much greater dependence onHSF1 function to maintain proliferation and survival than their nontransformed counterparts.
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Reduced levels of hsp90 compromise steroid receptor action in vivo
Didier Picard,Bushra Khursheed,Michael J. Garabedian,Marc G. Fortin,Marc G. Fortin,Susan Lindquist,Keith R. Yamamoto +6 more
TL;DR: This work has taken advantage of the capacity of mammalian steroid receptors to function in yeast and constructed a strain of Saccharomyces cerevisiae in which hsp90 expression was regulatable and could be reduced more than 20-fold relative to wild type, providing the first biological evidence that hSp90 acts in the signal transduction pathway for steroid receptors.
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Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology
Tiago F. Outeiro,Susan Lindquist +1 more
TL;DR: This readily manipulable system provides an opportunity to dissect the molecular pathways underlying normal alpha-synuclein biology and the pathogenic consequences of its misfolding.
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Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
Mikko Taipale,Irina Krykbaeva,Martina Koeva,Can Kayatekin,Kenneth D. Westover,Georgios I. Karras,Susan Lindquist,Susan Lindquist +7 more
TL;DR: In this paper, the authors systematically and quantitatively surveyed most human kinases, transcription factors, and E3 ligases for interaction with HSP90 and its cochaperone CDC37.
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Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition
Thomas Scheibel,Raghuveer Parthasarathy,George J. Sawicki,Xiao-Min Lin,Heinrich M. Jaeger,Susan Lindquist +5 more
TL;DR: The use of self-assembling amyloid protein fibers to construct nanowire elements to demonstrate the conductive properties of a solid metal wire, such as low resistance and ohmic behavior is described.