S
Susan Lindquist
Researcher at Massachusetts Institute of Technology
Publications - 443
Citations - 86482
Susan Lindquist is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Heat shock protein & Saccharomyces cerevisiae. The author has an hindex of 147, co-authored 440 publications receiving 81067 citations. Previous affiliations of Susan Lindquist include University of Illinois at Chicago & Howard Hughes Medical Institute.
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Journal ArticleDOI
BETASCAN: Probable β-amyloids Identified by Pairwise Probabilistic Analysis
TL;DR: The program, BETASCAN, calculates likelihood scores for potential β-strands and strand-pairs based on correlations observed in parallel β-sheets and suggests multiple alternate folding patterns and assigns relative a priori probabilities based solely on amino acid sequence, probability tables, and pre-chosen parameters.
Journal ArticleDOI
Translational efficiency of heat-induced messages in Drosophila melanogaster cells.
TL;DR: Ribosomes were found to initiate on heat-induced messages in Drosophila with a frequency of between 9 and 14 initiations per minute at 37 °C, close to that reported for other eukaryotic systems at similar temperatures.
Journal ArticleDOI
[PSI+]: An Epigenetic Modulator of Translation Termination Efficiency
Tricia R. Serio,Susan Lindquist +1 more
TL;DR: The series of experiments supporting the yeast prion hypothesis are reviewed and another look is provided at the 30 years of work preceding this theory in light of the current state of knowledge.
Journal ArticleDOI
Sensitivity-enhanced NMR reveals alterations in protein structure by cellular milieus.
Kendra K. Frederick,Vladimir K. Michaelis,Björn Corzilius,Ta-Chung Ong,Angela C. Jacavone,Robert G. Griffin,Susan Lindquist +6 more
TL;DR: In this article, the same authors applied DNP NMR to investigate the structure of a protein containing both an environmentally sensitive folding pathway and an intrinsically disordered region, the yeast prion protein Sup35.
Book ChapterDOI
Analysis of prion factors in yeast.
TL;DR: The chapter reviews the principal techniques used for genetic, cell biological, and biochemical characterization of yeast prions and focuses on [ PSI +]; however, [ URE3 ] and composite prions are also discussed for comparison.