S
Susan Lindquist
Researcher at Massachusetts Institute of Technology
Publications - 443
Citations - 86482
Susan Lindquist is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Heat shock protein & Saccharomyces cerevisiae. The author has an hindex of 147, co-authored 440 publications receiving 81067 citations. Previous affiliations of Susan Lindquist include University of Illinois at Chicago & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Motor Mechanism for Protein Threading through Hsp104
Petra Wendler,James Shorter,David Snead,Celia Plisson,Daniel K. Clare,Susan Lindquist,Helen R. Saibil +6 more
TL;DR: The authors' cryoelectron microscopy maps of Hsp104 hexamers reveal substantial domain movements upon ATP binding and hydrolysis in the first nucleotide-binding domain (NBD1), enabling a clockwise handover of substrate in the NBD1 ring and coordinated substrate binding between NBD 1 and NBD2.
Journal ArticleDOI
Unraveling Infectious Structures, Strain Variants and Species Barriers for the Yeast Prion [PSI+]
Peter M. Tessier,Susan Lindquist +1 more
TL;DR: This Perspective highlights recent studies of the yeast prion [PSI+], using various biochemical and structural methods, that have begun to illuminate the molecular mechanisms by which self-perpetuating prions encipher such biological activities.
Journal ArticleDOI
Subunit interactions influence the biochemical and biological properties of Hsp104.
TL;DR: Interactions between subunits influence the ATPase activity of Hsp104, play a vital role in its biological functions, and provide a mechanism for conditionally inactivating Hsp 104 function in vivo.
Journal ArticleDOI
An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists
Daniel F. Jarosz,Daniel F. Jarosz,Alex K. Lancaster,Alex K. Lancaster,Alex K. Lancaster,Jessica C.S. Brown,Susan Lindquist,Susan Lindquist +7 more
TL;DR: It is reported that de novo rates of [GAR(+)] appearance correlate with the yeast's ecological niche and is a broadly conserved adaptive strategy that links environmental and social cues to heritable changes in metabolism.
Journal ArticleDOI
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia
Grzegorz Sienski,Priyanka Narayan,Priyanka Narayan,Priyanka Narayan,Julia Maeve Bonner,Julia Maeve Bonner,Nora Kory,Sebastian Boland,Aleksandra Alicja Arczewska,William T. Ralvenius,Leyla Anne Akay,Elana Lockshin,Liang He,Blerta Milo,Agnese Graziosi,Valeriya Baru,Caroline A. Lewis,Manolis Kellis,David M. Sabatini,Li-Huei Tsai,Li-Huei Tsai,Susan Lindquist,Susan Lindquist +22 more
TL;DR: In this paper, the E4 allele of the apolipoprotein E gene (APOE) has been established as a genetic risk factor for many diseases including cardiovascular diseases and Alzheimer's disease (AD).