S
Susan Lindquist
Researcher at Massachusetts Institute of Technology
Publications - 443
Citations - 86482
Susan Lindquist is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Heat shock protein & Saccharomyces cerevisiae. The author has an hindex of 147, co-authored 440 publications receiving 81067 citations. Previous affiliations of Susan Lindquist include University of Illinois at Chicago & Howard Hughes Medical Institute.
Papers
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Yeast Reveal a ‘Druggable’ Rsp5/Nedd4 Network That Ameliorates α-Synuclein Toxicity in Neurons
Nathan T. Jui,Stephen L. Buchwald,Susan Lindquist,Daniel F. Tardiff,Vikram Khurana,Mitali A. Tambe,Michelle L. Thompson,Chee Yeun Chung,Hari B. Kamadurai,Hyoung Tae Kim,Alex K. Lancaster,Kim A. Caldwell,Guy A. Caldwell,Jean-Christophe Rochet +13 more
Book ChapterDOI
The yeast prion [PSI+]: molecular insights and functional consequences
Tricia R. Serio,Susan Lindquist +1 more
TL;DR: This chapter focuses on recent advances in the understanding of the molecular processes underlying the inheritance and functional consequences of the Saccharomyces cerevisiaeprion [PSI+], and a fundamentalUnderstanding of the regulation of the [ PSI + ] prion cycle in vivo remains elusive.
Journal ArticleDOI
The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion.
TL;DR: It is demonstrated that the ability to untangle aggregated proteins is conserved between the S. pombe and S. cerevisiae Hsp104 homologs, and points to a role of the CTD in the propagation ofThe S. Cerevisiae [PSI+] prion.
Journal ArticleDOI
Aggregation and Fibril Structure of AβM01-42 and Aβ1-42
Robert Silvers,Michael T. Colvin,Kendra K. Frederick,Angela C. Jacavone,Susan Lindquist,Sara Linse,Robert G. Griffin +6 more
TL;DR: Aβ aggregation and high-resolution structures of Aβ fibrils and oligomers are vital to elucidating relevant details of neurodegeneration in Alzheimer's disease, which will facilitate the rational design of diagnostic and therapeutic protocols.