S
Susan Lindquist
Researcher at Massachusetts Institute of Technology
Publications - 443
Citations - 86482
Susan Lindquist is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Heat shock protein & Saccharomyces cerevisiae. The author has an hindex of 147, co-authored 440 publications receiving 81067 citations. Previous affiliations of Susan Lindquist include University of Illinois at Chicago & Howard Hughes Medical Institute.
Papers
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Journal ArticleDOI
Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism.
Daniel F. Tardiff,Lauren E. Brown,Xiaohui Yan,Richard Trilles,Nathan T. Jui,M. Inmaculada Barrasa,Kim A. Caldwell,Guy A. Caldwell,Scott E. Schaus,Susan Lindquist,Susan Lindquist +10 more
TL;DR: The identification of a new cytoprotective scaffold that requires metal-binding underscores the critical role of metal phenomenology in mediating Aβ toxicity and demonstrates the valuable potential of synergistic compounds to enhance on-target activities, while mitigating deleterious off-target effects.
Patent
Yeast cells expressing amyloid beta and uses therefor
TL;DR: In this paper, yeast cells expressing a polypeptide comprising a signal sequence and a human amyloid beta protein were screened to identify compounds that prevent or suppress toxicity and genetic suppressors or enhancers.
Journal ArticleDOI
Role of HSP90 in the Regulation of de Novo Purine Biosynthesis.
Anthony M. Pedley,Georgios I. Karras,Xin Zhang,Susan Lindquist,Susan Lindquist,Stephen J. Benkovic +5 more
TL;DR: A new-found biochemical mechanism for the regulation of de novo purine biosynthetic enzymes mediated through HSP90 is presented and the combined efforts of molecular chaperones in the maturation of PPAT and FGAMS result in purinosome formation and are likely essential for enhancing the rate of purine production to meet intracellular purine demand.
Hsp90 as a capacitor of phenotypic
Todd A. Sangster,Susan Lindquist +1 more
TL;DR: Manipulating Hsp90’s buffering capacity offers a tool for harnessing cryptic genetic variation and for elucidating the interplay between genotypes, environments and stochastic events inthe determination of phenotype.
Journal ArticleDOI
Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates
Willmen Youngsaye,Benjamin Vincent,Cathy L Hartland,Barbara Morgan,Sara J. Buhrlage,Stephen Johnston,Joshua A. Bittker,Lawrence MacPherson,Sivaraman Dandapani,Michelle Palmer,Luke Whitesell,Susan Lindquist,Stuart L. Schreiber,Stuart L. Schreiber,Benito Munoz +14 more
TL;DR: In this paper, a piperazinyl quinoline was identified as a new small-molecule probe (ML189) satisfying these criteria, while having no antifungal activity when administered as a single agent.