Susan Lindquist

TL;DR: In this article, the authors provide compounds of Formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof for inhibiting fungal or parasitic growth, which are useful as inhibitors of glycosylphosphatidylinositol (GPI)-anchor biosynthesis.

TL;DR: In this paper, the authors show that when purified Sup35 and Hsp104 are mixed, the circular dichroism (CD) spectrum differs from that predicted by the addition of the proteins' individual spectra, and the ATPase activity of Sup35 is inhibited.

TL;DR: This article showed that transient loss of heat shock protein 90 function can promote a nongenetic inheritance of a translational state affecting specific mRNAs, introducing a mechanism by which Hsp90 can promote phenotypic variation.

TL;DR: This chapter explores yeast cells as a discovery platform for Parkinson's disease (PD) and finding genetic factors and chemical compounds that modify the toxicity of proteins that are prone to misfoldings and producing toxic gain-of-function phenotypes in man.

TL;DR: The method allows determination of target specificities of both ATP-competitive and allosteric inhibitors in the kinases' native cellular context in high throughput and is applicable to other chaperones and target classes by assaying HSP70/steroid hormone receptor and CDC37/kinase interactions, suggesting that chaperone interactions will have broad application in detecting drug-target interactions in vivo.