S
Susan Lindquist
Researcher at Massachusetts Institute of Technology
Publications - 443
Citations - 86482
Susan Lindquist is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Heat shock protein & Saccharomyces cerevisiae. The author has an hindex of 147, co-authored 440 publications receiving 81067 citations. Previous affiliations of Susan Lindquist include University of Illinois at Chicago & Howard Hughes Medical Institute.
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Rapid iPSC inclusionopathy models shed light on formation, consequence and molecular subtype of α-synuclein inclusions
Isabel Lam,Alain Ndayisaba,Amanda J Lewis,YuHong Fu,Giselle T. Sagredo,Ludovica Zaccagnini,Jackson Sandoe,Ricardo L. Sanz,Aazam Vahdatshoar,Timothy D. Martin,Nader Morshed,Toru Ichihashi,Arati Tripathi,Nagendran Ramalingam,Charlotte Oettgen-Suazo,Theresa Bartels,Max Schäbinger,Erinc Hallacli,Xin Jiang,Amrita Verma,Challana Tea,Zichen Wang,Hiroyuki Hakozaki,Xiao Yu,Kelly Hyles,Chan Woo Park,Thorold W. Theunissen,Haoyi Wang,Rudolf Jaenisch,Susan Lindquist,Beth Stevens,Nadia Stefanova,Gregor K. Wenning,Kelvin C. Luk,Rosario Sánchez Pernaute,Juan Carlos Gómez-Esteban,Daniel Felsky,Yasujiro Kiyota,Nidhi Sahni,Song Stephen Yi,Chee Yeun Chung,Henning Stahlberg,Isidro Ferrer,Johannes Schöneberg,Stephen J. Elledge,Ulf Dettmer,Glenda M. Halliday,Tim Bartels,Vikram Khurana +48 more
TL;DR: In this paper , the authors developed an iPSC toolbox utilizing piggyBac-based or targeted transgenes to rapidly induce CNS cells with concomitant expression of aggregation-prone proteins.
Phenotypic screens for compounds that target the cellular pathologies underlying Parkinson's disease
TL;DR: Parkinson's disease (PD) is a devastating neurodegenerative disease that affects over one million patients in the US as discussed by the authors. Yet, no disease modifying drugs exist, only those that temporarily alleviate symptoms.
Patent
Protein Aggregation Domains and Methods of Use Thereof
Susan Lindquist,Peter M. Tessier +1 more
TL;DR: Using the Sup35 prion proteins of two distantly related yeast species, it was established that prion replication is initiated by small elements of primary sequence, which can be identified using arrays of short peptides as discussed by the authors.
Patent
Prion-based manipulation of yeast fermentation and growth
TL;DR: In this paper, a method for identifying a modulator of a prion of interest is presented, which involves providing a bacterially conditioned medium, at least one fraction of the medium with a non-bacterial cell, and monitoring the cell for alteration of a phenotype assocatied with the prion.