S
Susan Lindquist
Researcher at Massachusetts Institute of Technology
Publications - 443
Citations - 86482
Susan Lindquist is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Heat shock protein & Saccharomyces cerevisiae. The author has an hindex of 147, co-authored 440 publications receiving 81067 citations. Previous affiliations of Susan Lindquist include University of Illinois at Chicago & Howard Hughes Medical Institute.
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Journal ArticleDOI
Three quite different things that matter to me.
TL;DR: I'm grateful to be asked to comment on cell biology and the next 50 years and to focus on just three quite different things that particularly matter to me.
Proceedings ArticleDOI
Abstract P6-15-06: Heat Shock Protein 90 Inhibition Limits the Emergence of Tamoxifen Resistance
TL;DR: In conclusion, inhibition of the molecular chaperone heat shock protein 90 (Hsp90) is examined as an alternative approach to targeting ER function, one that could be used in combination with Tam to prevent resistance and provide more durable disease control and provide a strong pre-clinical rationale for evaluating combined Tamoxifen- Hsp90 inhibitor treatment in patients.
Journal ArticleDOI
Inactivating Heat Shock Factor 1 (HSF1) in Acute Myeloid Leukemia By Pharmacological Inhibition of eIF4a: A Promising Therapeutic Approach
Jo Ishizawa,Rodrigo Jacamo,Kensuke Kojima,Kensuke Kojima,Dhruv Chachad,Vivian Ruvolo,Peter P. Ruvolo,Weiguo Zang,Yoko Tabe,Marina Konopleva,William G. Devine,Susan Lindquist,John A. Porco,Luke Whitesell,Michael Andreeff +14 more
TL;DR: It is demonstrated that inactivation of HSF1 in acute myeloid leukemias (AMLs) by RHT exerts pronounced apoptogeniceffects with preferential activity against FLT3-ITD mutant cells in cell culture and in mice.
Proceedings ArticleDOI
Abstract C132: Targeting heat shock factor 1 improves the antitumor efficiency of hyperthermia.
TL;DR: It is found that inhibiting HSF1 in solid tumors increases the efficiency of hyperthermia as an anticancer treatment, and targeting heat shock factor 1 improves the antitumor efficiency ofhyperthermia.
Posted ContentDOI
Transient Hsp90 suppression promotes a heritable change in protein translation
Peter Tsvetkov,Zarina Brune,Timothy J. Eisen,Sven U. Heinrich,Gregory A. Newby,Erinc Hallacli,Can Kayatekin,David Pincus,Susan Lindquist,Susan Lindquist +9 more
TL;DR: The role of heat shock protein 90 (Hsp90) chaperone functions as a protein-folding buffer and plays a unique role promoting the evolution of new heritable traits as mentioned in this paper.