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Susan P.C. Cole
Researcher at Queen's University
Publications - 243
Citations - 25942
Susan P.C. Cole is an academic researcher from Queen's University. The author has contributed to research in topics: Multidrug Resistance Protein 1 & ATP-binding cassette transporter. The author has an hindex of 76, co-authored 243 publications receiving 24995 citations. Previous affiliations of Susan P.C. Cole include University of Arizona & Cancer Research Institute.
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Journal ArticleDOI
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
Susan P.C. Cole,Gabu Bhardwaj,James H. Gerlach,J. E. Mackie,Caroline E. Grant,Kurt C. Almquist,Alistair J. Stewart,Ebba U. Kurz,A. M. V. Duncan,Roger G. Deeley +9 more
TL;DR: Reversion to drug sensitivity was associated with loss of gene amplification and a marked decrease in mRNA expression, and the mRNA encodes a member of the ATP-binding cassette transmembrane transporter superfamily.
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Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
TL;DR: The role of these four ABC transporter proteins in protecting tissues from a variety of toxicants is discussed and species variations in substrate specificity and tissue distribution of these transporters are addressed since these properties have implications for in vivo models of toxicity used for drug discovery and development.
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The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.
Journal Article
Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.
Susan P.C. Cole,Kathryn E. Sparks,Karen Fraser,Douglas W. Loe,Caroline E. Grant,Gerald M. Wilson,Roger G. Deeley +6 more
TL;DR: Transfecting two different eukaryotic expression vectors containing MRP complementary DNA into HeLa cells to study the pharmacological phenotype produced exclusively by overexpression of human MRP indicates that drug-resistant cell lines generated by transfection with MRp complementary DNA display some but not all of the characteristics of MRP-overexpressing cell lines produced by drug selection in vitro.
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Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
TL;DR: What is known of the structure of the MRPs and the mechanisms by which they recognize and transport their diverse substrates are described and evidence that they may be involved in the clinical drug resistance of various forms of cancer is summarized.