S
Susan S. Taylor
Researcher at University of California, San Diego
Publications - 541
Citations - 45257
Susan S. Taylor is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Protein kinase A & Protein subunit. The author has an hindex of 104, co-authored 518 publications receiving 42108 citations. Previous affiliations of Susan S. Taylor include San Diego Supercomputer Center & Takeda Pharmaceutical Company.
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Journal ArticleDOI
Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase
Daniel R. Knighton,Jianhua Zheng,L. F. Ten Eyck,L. F. Ten Eyck,Victor A. Ashford,Nguyen-Huu Xuong,Susan S. Taylor,Janusz M. Sowadski +7 more
TL;DR: The crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase complexed with a 20-amino acid substrate analog inhibitor has been solved and partially refined at 2.7 A resolution to an R factor of 0.212.
Journal ArticleDOI
Identification of a signal for rapid export of proteins from the nucleus
TL;DR: The heat-stable inhibitor of cAPK contains a nuclear export signal that triggers rapid, active net extrusion of the C-PKl complex from the nucleus, and this NES (residues 35-49), fused or conjugated to heterologous proteins, was sufficient for rapid nuclear export.
Journal ArticleDOI
Camp-Dependent Protein Kinase: Framework for a Diverse Family of Regulatory Enzymes
TL;DR: Although the next chapter in the history of cAPK will undoubtedly include three-dimensional structures, the chemical information remains as an essential complement for interpreting those structures and eventually understanding the molecular events associated with catalysis and activation.
Journal ArticleDOI
Regulation of protein kinases; controlling activity through activation segment conformation.
TL;DR: This work examines protein kinase crystal structures using a structural bioinformatics approach to understand how the conformation of the activation segment controls kinase activity.
Journal ArticleDOI
Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase
Daniel R. Knighton,Jianhua Zheng,Lynn F. Ten Eyck,Lynn F. Ten Eyck,Nguyen-Huu Xuong,Susan S. Taylor,Janusz M. Sowadski +6 more
TL;DR: The structure of a 20-amino acid peptide inhibitor bound to the catalytic subunit of cyclic AMP-dependent protein kinase, and its interactions with the enzyme, are described and the x-ray crystal structure of the complex is the basis of the analysis.