Susana Liu

TL;DR: Findings strongly support the hypothesis that inhibition of PDE4D is pivotal to the anesthesia-reversing effect of PMNPQ and is likely responsible for emesis induced by PDE 4 inhibitors.

TL;DR: The results suggest that the cPLA2 plays an important role in the generation of free AA for 12-HETE biosynthesis in platelets and affects the cyclooxygenase pathway in addition to AA release.

TL;DR: It is shown that specific inhibition of PDE4 preferentially blocks the production of Th1 versus Th2 effector cytokines in vitro and rolipram and L-826,141 are potent inhibitors of CD3-plus CD28-stimulated IL-2 production in naive human T cells.

TL;DR: The activation of CFTR-mediated chloride secretion by phosphodiesterase (PDE) 4 inhibitors in T84 monolayer using 125I anion as tracer suggests that PDE3 and PDE4 form the major cAMP diffusion barrier in T 84 cells to ensure a compartmentalized CFTR signaling.

TL;DR: The attenuated inflammatory and allergic responses from the potent and preferential PDE4 inhibition of ibudilast may have contributed significantly to its beneficial pharmacological responses and distinguishes ibudILast from the other ophthalmic solutions in the treatment of ocular allergy.