Susana Ungaro Amadei

Bio: Susana Ungaro Amadei is an academic researcher from Sao Paulo State University. The author has contributed to research in topics: Breast feeding & Matrix metalloproteinase. The author has an hindex of 6, co-authored 18 publications receiving 90 citations.

A influência da deficiência estrogênica no processo de remodelação e reparação óssea

Abstract: Universidade Estadual Paulista Faculdade de Odontologia de Sao Jose dos Campos Departamento de Biociencias e Diagnostico Bucal

Influence of different durations of estrogen deficiency on alveolar bone loss in rats.

Abstract: The purpose of this study was to morphometrically evaluate the influence of different durations of ovariectomy-induced estrogen deficiency on alveolar bone loss associated with ligature-induced bone loss in rats. Sixty female Wistar rats were randomly assigned to ovariectomy (OVX test group) or sham operation (SHAM control group). The OVX and SHAM groups were each distributed into three subgroups of ten rats each according to the duration of estrogen deficiency (30, 60 and 90 postoperative days). In all groups, for the last 30 days of the experimental period, cotton ligatures were placed around the cervix of the right upper second molar; the contralateral tooth was left unligated to serve as a control. The maxillary bones were removed, and the alveolar bone loss was analyzed by measuring the distance between the cementoenamel junction and the alveolar bone crest at the buccal site of the right upper second molar. A comparison between the ligated and unligated groups verified the presence of ligature-induced alveolar bone loss (p 0.05). A significant increase in bone loss was observed when ligation occurred 90 days after ovariectomy compared with the sham group (p < 0.05). These results demonstrate that long-term estrogen deficiency affects ligature-induced alveolar bone loss.

Prescrição medicamentosa no tratamento odontológico de grávidas e lactantes / Drug prescription in the dentistry treatment of pregnant and lactating women

Abstract: A terapeutica medicamentosa durante a gravidez deve ser cuidadosa, pois alguns farmacos podem causar serios efeitos adversos a mae e ao feto. E imprescindivel que a terapeutica cautelosa estenda-se pelo periodo de amamentacao, pois a maioria dos farmacos administrados as mulheres durante a lactacao pode ser detectada no leite materno. A prescricao para tais pacientes deve ser realizada de forma racional e cuidadosa, evitando-se desta forma, os efeitos colaterais e as reacoes adversas. E de extrema importância que o cirurgiao-dentista, como profissional da saude, avalie a necessidade, a eficacia e a relacao risco/beneficio dos medicamentos que podem ser prescritos para tais pacientes, alem das alteracoes corporeas e bucais decorrentes desta fase. Para tanto, a proposta deste trabalho foi realizar uma revisao bibliografica com o objetivo de esclarecer o profissional, no que se refere a prescricao de medicamentos no atendimento odontologico a pacientes gestantes e lactantes. Termos de indexacao: Aleitamento materno. Gestantes. Prescricao de medicamentos. ABSTRACT The drug prescription during the pregnancy must be carefully conducted, since some drugs can cause serious adverse reaction to both mother and fetus. Moreover, that such careful prescription must be conducted during the whole breastfeeding time, because a lot of drugs, which are prescript to women during the breastfeeding time, can be found in breast milk. The drug prescription for these patients must be done in a rational and careful way, avoiding the adverse effects. It is extremely important that the dentist, as a health professional, evaluate the need, the efficacy, the benefits and the risks of the drugs which can be prescribed for such patients, besides knowing the body and oral alterations resulting from this phase. Therefore, the proposal of this paper was to conduct a literature review aiming to inform dentists about drug prescription in the dentistry treatment of pregnant and lactating patients. Indexing terms: Breast feeding. Pregnant women. Drug prescriptions.

Prevalência de processos proliferativos não neoplásicos na cavidade bucal: estudo retrospectivo de quarenta anos Prevalence of non neoplastic proliferative lesions in oral cavities: a forty- year retrospective study

Abstract: Non-neoplastic proliferative lesions (NNPL) are frequently diagnosed in oral mucosa and are characterized by tissue proliferation, primarily with an inflammatory origin and without a neoplastic aspect. The aim of this work was to present an epidemiological study of NNPL cases from the Surgery Pathology Files of the School of Dentistry at Sao Jose dos Campos (UNESP) over a period of forty years. A total of 1,364 NNPL cases were analyzed (18.63% of all 7,300 cases in the archive). In the NNPL cases, 76.76% were diagnosed as fibrous inflammatory hyperplasia, 9.68% as pyogenic granuloma, 8.58% as peripheral ossifying/cementifying fibroma and 4.99% as peripheral giant cell granuloma. Patient age, gender, race and the anatomical site of the lesion(s) were also investigated. Among the NNPL cases, the most prevalent anatomical site was the gingiva (30.94%), and most cases occurred in female patients (65.61%), caucasians (75.8%) and at the 5th decade of life (21.77%), which is in agreement with the literature database. Since there is a high prevalence of NNPL in this population, a better understanding of the features of these lesions by the dentist is necessary. With these data, he will be

Increased concentration of 8-hydroxy-2'-deoxyguanosine in follicular fluid of infertile women with endometriosis.

Abstract: Impaired oocyte quality and oxidative stress might be involved in the pathogenesis of endometriosis-related infertility. To improve our understanding of the role of oxidative stress in this condition, we compare eight oxidative stress markers from each stage, including the simultaneous analysis of lipids, proteins and DNA damage, in the serum and follicular fluid of infertile women with endometriosis and infertile controls undergoing controlled ovarian stimulation for intracytoplasmic sperm injection. In total, 87 serum samples (43 with endometriosis, 44 controls) and 61 follicular fluid samples (29 with endometriosis, 32 controls) free of blood contamination upon visual inspection and presenting granulosa cells alone or granulosa cells plus a retrieved mature oocyte were collected on the day of oocyte retrieval. Total hydroperoxides, malondialdehyde, advanced oxidation protein products, glutathione, superoxide dismutase (SOD) and total antioxidant capacity (TAC) were determined by spectrophotometry, vitamin E by high-performance liquid chromatography and 8-hydroxy-2′–deoxyguanosine (8OHdG) by enzyme-linked immunosorbent assay. The endometriosis group showed higher serum concentrations of glutathione and SOD, lower serum concentrations of TAC and higher follicular concentrations of 8OHdG and vitamin E compared with infertile controls. These data indicate both systemic and follicular oxidative stress in infertile patients with endometriosis. For the first time, we demonstrate the presence of oxidative DNA damage, represented by higher 8OHdG concentrations in the follicular microenvironment of these patients, possibly related to compromised oocyte quality and associated with the pathogenesis of endometriosis-related infertility.

Updating the role of matrix metalloproteinases in mineralized tissue and related diseases

Abstract: Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play several key roles in the installation of heart and blood vessel related diseases and cancer, ranging from accelerating metastatic cells to ectopic vascular mineralization by smooth muscle cells in complementary manner. The tissue inhibitors of MMPs (TIMPs) have an important role in controlling proteolysis. Paired with the post-transcriptional efficiency of specific miRNAs, they modulate MMP performance. If druggable, these molecules are suggested to be a platform for development of "smart" medications and further clinical trials. Thus, considering the pleiotropic effect of MMPs on mammals, the purpose of this review is to update the role of those multifaceted proteases in mineralized tissues in health, such as bone, and pathophysiological disorders, such as ectopic vascular calcification and cancer.

Pyogenic granuloma on the upper lip: an unusual location

Abstract: Pyogenic granuloma (PG) is a benign non-neoplastic mucocutaneous lesion. It is a reactional response to constant minor trauma and might be related to hormonal changes. In the mouth, PG is manifested as a sessile or pedunculated, resilient, erythematous, exophytic and painful papule or nodule with a smooth or lobulated surface that bleeds easily. PG preferentially affects the gingiva, but may also occur on the lips, tongue, oral mucosa and palate. The most common treatment is surgical excision. This paper describes a mucocutaneous PG on the upper lip, analyzing the clinical characteristics and discussing the features that distinguish this lesion from other similar oral mucosa lesions. The diagnosis of oral lesions is complex and leads the dentist to consider distinct lesions with different diagnostic methods. This case report with a 4 year-follow-up calls the attention to the uncommon mucocutaneous labial location of PG and to the fact that surgical excision is the safest method for diagnosis and treatment of PG of the lip, even when involving the mucosa and skin