S
Susanne Opravil
Researcher at Research Institute of Molecular Pathology
Publications - 15
Citations - 9135
Susanne Opravil is an academic researcher from Research Institute of Molecular Pathology. The author has contributed to research in topics: Histone methyltransferase & Histone code. The author has an hindex of 15, co-authored 15 publications receiving 8594 citations.
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Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.
Journal ArticleDOI
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.
Antoine H.F.M. Peters,Dónal O'Carroll,Harry Scherthan,Karl Mechtler,Stephan Sauer,Christian Schöfer,Klara Weipoltshammer,Michaela Pagani,Monika Lachner,Alexander Kohlmaier,Susanne Opravil,Michael P. Doyle,Maria Sibilia,Thomas Jenuwein +13 more
TL;DR: In vivo data assign a crucial role for pericentric H3-K9 methylation in protecting genome stability, and define the Suv39h HMTases as important epigenetic regulators for mammalian development.
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Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin
Antoine H.F.M. Peters,Stefan Kubicek,Karl Mechtler,Roderick J. O'Sullivan,Alwin A.H.A. Derijck,Laura Perez-Burgos,Alexander Kohlmaier,Susanne Opravil,Makoto Tachibana,Yoichi Shinkai,Joost H.A. Martens,Thomas Jenuwein +11 more
TL;DR: The data underscore the selective presence of distinct histone lysine methylation states in partitioning chromosomal subdomains but also reveal a surprising plasticity in propagating methylation patterns in eukaryotic chromatin.
Journal ArticleDOI
p53 is regulated by the lysine demethylase LSD1
Jing Huang,Roopsha Sengupta,Alexsandra Espejo,Min Gyu Lee,Jean Dorsey,Mario Richter,Susanne Opravil,Ramin Shiekhattar,Mark T. Bedford,Thomas Jenuwein,Shelley L. Berger +10 more
TL;DR: Lysine methylation provides similar regulatory complexity for non-histone proteins and for histones and that the methylation status at a single lysine residue confers distinct regulatory output.
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The profile of repeat‐associated histone lysine methylation states in the mouse epigenome
Joost H.A. Martens,Roderick J. O'Sullivan,Ulrich Braunschweig,Susanne Opravil,Martin Radolf,Peter Steinlein,Thomas Jenuwein +6 more
TL;DR: A profile of repressive histone lysine methylation states for the repetitive complement of four distinct mouse epigenomes is defined and tandem repeats and dsRNA are suggested as primary triggers for more stable chromatin imprints.