S
Sushmita Jha
Researcher at Indian Institute of Technology, Jodhpur
Publications - 32
Citations - 2575
Sushmita Jha is an academic researcher from Indian Institute of Technology, Jodhpur. The author has contributed to research in topics: Inflammasome & Inflammation. The author has an hindex of 15, co-authored 28 publications receiving 2090 citations. Previous affiliations of Sushmita Jha include Indian Institutes of Technology & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Haitao Wen,Denis Gris,Yu Lei,Sushmita Jha,Lu Zhang,Max Tze Han Huang,Willie June Brickey,Jenny P.-Y. Ting +7 more
TL;DR: It is shown that the saturated fatty acid palmitate, but not unsaturated oleate, induces the activation of the NLRP3-ASC inflammasome, causing caspase-1, IL-1β and IL-18 production, which affects insulin sensitivity through tumor necrosis factor–independent and dependent pathways.
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NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
Leslie Freeman,Haitao Guo,Clément N. David,W. June Brickey,Sushmita Jha,Sushmita Jha,Jenny P.-Y. Ting +6 more
TL;DR: It is revealed that lysophosphatidylcholine (LPC), a molecule associated with neurodegeneration and demyelination, elicits NLRP3 and NLRC4 inflammasome activation in microglia and astrocytes, which are central players in neuroinflammation.
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The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18
Sushmita Jha,Siddharth Y. Srivastava,Willie June Brickey,Heather A. Iocca,Arrel D. Toews,James P. Morrison,Vivian S. Chen,Vivian S. Chen,Denis Gris,Glenn K. Matsushima,Jenny P.-Y. Ting +10 more
TL;DR: It is suggested that NLRP3 plays an important role in a model of multiple sclerosis by exacerbating CNS inflammation, and this is partly mediated by caspase-1 and IL-18.
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Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases.
Sushmita Jha,Jenny P.-Y. Ting +1 more
TL;DR: The role of the inflammasome NLR proteins in innate immunity and inflammatory diseases is summarized and the possible utility of some of these NLRs as pharmacological targets is explored.
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Mitochondrial Dysfunction and Alzheimer's Disease: Role of Microglia.
Ishan Agrawal,Sushmita Jha +1 more
TL;DR: This chapter explores the role of mitochondrial dysfunction in microglia in case of AD and how understanding microglial physiology and mitochondrial dysfunction will enable better therapeutic interventions.