S
Suyash Mohan
Researcher at University of Pennsylvania
Publications - 177
Citations - 3988
Suyash Mohan is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Magnetic resonance imaging. The author has an hindex of 23, co-authored 145 publications receiving 2507 citations. Previous affiliations of Suyash Mohan include University of Arkansas for Medical Sciences & Hospital of the University of Pennsylvania.
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Journal ArticleDOI
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.
Donald M. O'Rourke,MacLean Nasrallah,Arati Desai,J. Joseph Melenhorst,Keith Mansfield,Jennifer J.D. Morrissette,Maria Martinez-Lage,Steven Brem,Eileen Maloney,Angela Shen,Randi Isaacs,Suyash Mohan,Gabriela Plesa,Simon F. Lacey,Jean-Marc Navenot,Zhaohui Zheng,Bruce L. Levine,Hideho Okada,Carl H. June,Jennifer Brogdon,Marcela V. Maus +20 more
TL;DR: The initial experience with CAR T cells in recurrent GBM suggests that although intravenous infusion results in on-target activity in the brain, overcoming the adaptive changes in the local tumor microenvironment and addressing the antigen heterogeneity may improve the efficacy of EGFRvIII-directed strategies in GBM.
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Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies
Kevin R. Parker,Denis Migliorini,Denis Migliorini,Eric Perkey,Kathryn E. Yost,Aparna Bhaduri,Puneet Bagga,Mohammad Haris,Neil E. Wilson,Fang Liu,Khatuna Gabunia,John Scholler,Thomas J. Montine,Vijay Bhoj,Ravinder Reddy,Suyash Mohan,Ivan Maillard,Arnold R. Kriegstein,Carl H. June,Howard Y. Chang,Avery D. Posey,Ansuman T. Satpathy +21 more
TL;DR: It is reported that mural cells, which surround the endothelium and are critical for blood-brain-barrier integrity, express CD19, suggesting an on-target mechanism for neurotoxicity in CD19-directed therapies and highlighting the utility of human single-cell atlases for designing immunotherapies.
Journal ArticleDOI
Differential diagnosis for bilateral abnormalities of the basal ganglia and thalamus.
TL;DR: In this paper, the authors used confirmatory neuroimaging investigations, especially diffusion-weighted imaging, MR angiography, MR venography, and MR spectroscopy during the same examination, to help improve characterization of these abnormalities and help narrow the differential diagnosis.
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Emerging Applications of Artificial Intelligence in Neuro-Oncology
TL;DR: By providing in vivo markers of spatial and molecular heterogeneity, these AI-based radiomic and radiogenomic tools have the potential to stratify patients into more precise initial diagnostic and therapeutic pathways and enable better dynamic treatment monitoring in this era of personalized medicine.
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Differentiating Tumor Progression from Pseudoprogression in Patients with Glioblastomas Using Diffusion Tensor Imaging and Dynamic Susceptibility Contrast MRI
Sumei Wang,Maria Martinez-Lage,Y. Sakai,Sanjeev Chawla,Sungheon Kim,Michelle Alonso-Basanta,Robert A. Lustig,Steven Brem,Suyash Mohan,Ronald L. Wolf,Arati Desai,Harish Poptani +11 more
TL;DR: DTI and DSC perfusion imaging can improve accuracy in assessing treatment response and may aid in individualized treatment of patients with glioblastomas.