S
Sven H. Loosen
Researcher at University of Düsseldorf
Publications - 166
Citations - 2482
Sven H. Loosen is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 18, co-authored 100 publications receiving 1169 citations. Previous affiliations of Sven H. Loosen include RWTH Aachen University.
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Journal ArticleDOI
Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer.
Jakob Nikolas Kather,Alexander T. Pearson,Niels Halama,Dirk Jäger,Jeremias Krause,Sven H. Loosen,Alexander Marx,Peter Boor,Frank Tacke,Ulf P. Neumann,Heike I. Grabsch,Heike I. Grabsch,Takaki Yoshikawa,Hermann Brenner,Jenny Chang-Claude,Jenny Chang-Claude,Michael Hoffmeister,Christian Trautwein,Tom Luedde +18 more
TL;DR: It is shown that deep residual learning can predict MSI directly from H&E histology, which is ubiquitously available and has the potential to provide immunotherapy to a much broader subset of patients with gastrointestinal cancer.
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RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer
Anne T. Schneider,Jérémie Gautheron,Maria Feoktistova,Christoph Roderburg,Sven H. Loosen,Sanchari Roy,Fabian Benz,Peter Schemmer,Markus W. Büchler,Ueli Nachbur,Ulf P. Neumann,Rene Tolba,Mark Luedde,Jessica Zucman-Rossi,Diana Panayotova-Dimitrova,Martin Leverkus,Christian Preisinger,Frank Tacke,Christian Trautwein,Thomas Longerich,Mihael Vucur,Tom Luedde +21 more
TL;DR: It is suggested that RIPK1 collaborates with TRAF2 to inhibit murine and human hepatocarcinogenesis and caspase-8 hyperactivation in liver parenchymal cells promotes the spontaneous development of hepatocellular carcinoma.
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Diagnostic and prognostic biomarkers in cholangiocarcinoma.
Rocio I.R. Macias,Rocio I.R. Macias,Miroslaw Kornek,Pedro M. Rodrigues,Nuno A. Paiva,Rui E. Castro,Sabine K. Urban,Stephen P. Pereira,Massimiliano Cadamuro,Christian Rupp,Sven H. Loosen,Tom Luedde,Jesus M. Banales,Jesus M. Banales,Jesus M. Banales +14 more
TL;DR: This review summarizes and discusses the advances in the investigation of novel diagnostic and prognostic biomarkers in CCA and envisions the future directions in this field of research.
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Soluble Urokinase Receptor (SuPAR) in COVID-19-Related AKI.
Tariq U. Azam,Husam Shadid,Pennelope K. Blakely,Patrick O'Hayer,Hanna Berlin,Michael Pan,Peiyao Zhao,Lili Zhao,Subramaniam Pennathur,Rodica Pop-Busui,Izzet Altintas,Jens Tingleff,Marius Ahm Stauning,Ove Andersen,Maria-Evangelia Adami,Nicky Solomonidi,Maria Tsilika,Pinkus Tober-Lau,Eleni Arnaoutoglou,Verena Keitel,Frank Tacke,Athanasios Chalkias,Sven H. Loosen,Evangelos J. Giamarellos-Bourboulis,Jesper Eugen-Olsen,Jochen Reiser,Salim S. Hayek +26 more
TL;DR: In this paper, the suPAR levels in patients hospitalized for coronavirus disease 2019 (COVID-19) were measured in plasma samples from 352 adult patients that had been collected within 48 hours of admission.
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Impact of the COVID-19 Pandemic on Cancer Diagnoses in General and Specialized Practices in Germany
TL;DR: In this article, the authors investigated the impact of the coronavirus disease 2019 (COVID-19) pandemic on cancer diagnosis in general and specialized practices in Germany and found that the number of new cancer diagnoses per general practice decreased significantly between March and May 2020 compared with the same period in 2019 (March: −12.0%, April: −27.6%, and May: −23.4%).