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Sven Kreiborg

Bio: Sven Kreiborg is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Craniofacial & Apert syndrome. The author has an hindex of 47, co-authored 193 publications receiving 6717 citations. Previous affiliations of Sven Kreiborg include Copenhagen University Hospital & Technical University of Denmark.


Papers
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Journal ArticleDOI
TL;DR: The method reconstructs, from radiographs of the hand, the borders of 15 bones automatically and then computes ldquointrinsicrdquo bone ages for each of 13 bones (radius, ulna, and 11 short bones) and transforms the intrinsic bone ages into Greulich Pyle or Tanner Whitehouse bone age.
Abstract: Bone age rating is associated with a considerable variability from the human interpretation, and this is the motivation for presenting a new method for automated determination of bone age (skeletal maturity). The method, called BoneXpert, reconstructs, from radiographs of the hand, the borders of 15 bones automatically and then computes ldquointrinsicrdquo bone ages for each of 13 bones (radius, ulna, and 11 short bones). Finally, it transforms the intrinsic bone ages into Greulich Pyle (GP) or Tanner Whitehouse (TW) bone age. The bone reconstruction method automatically rejects images with abnormal bone morphology or very poor image quality. From the methodological point of view, BoneXpert contains the following innovations: 1) a generative model (active appearance model) for the bone reconstruction; 2) the prediction of bone age from shape, intensity, and texture scores derived from principal component analysis; 3) the consensus bone age concept that defines bone age of each bone as the best estimate of the bone age of the other bones in the hand; 4) a common bone age model for males and females; and 5) the unified modelling of TW and GP bone age. BoneXpert is developed on 1559 images. It is validated on the Greulich Pyle atlas in the age range 2-17 years yielding an SD of 0.42 years [0.37; 0.47] 95% conf, and on 84 clinical TW-rated images yielding an SD of 0.80 years [0.68; 0.93] 95% conf. The precision of the GP bone age determination (its ability to yield the same result on a repeated radiograph) is inferred under suitable assumptions from six longitudinal series of radiographs. The result is an SD on a single determination of 0.17 years [0.13; 0.21] 95% conf.

333 citations

Journal ArticleDOI
TL;DR: Seven mutations in the SH3-binding protein SH3BP2 on chromosome 4p16.3 that cause cherubism are described.
Abstract: Cherubism (MIM 118400) is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws1 followed by development of fibrous tissue masses, which causes a characteristic facial swelling. Here we describe seven mutations in the SH3-binding protein SH3BP2 (MIM 602104) on chromosome 4p16.3 that cause cherubism.

329 citations

Journal ArticleDOI
TL;DR: A hypothesis is presented which links posturally induced stretching of the facial soft-tissue layer, craniofacial morphology and airway adequacy into a suggested cycle of factors related to cranioFacial morphogenesis.
Abstract: – A hypothesis is presented which links posturally induced stretching of the facial soft-tissue layer, craniofacial morphology and airway adequacy into a suggested cycle of factors related to craniofacial morphogenesis.

233 citations

Journal ArticleDOI
TL;DR: It was concluded that certain malocclusions, especially conspicuous occlusal and space anomalies, may adversely affect body image and self-concept, not only at adolescence but also in adulthood.

200 citations

Journal ArticleDOI
TL;DR: The purpose of the present investigation was to describe the formation, maturation and eruption of the dentition, including supernumerary teeth in a sample of patients with cleidocranial dysplasia, and hypothesized that the dental lamina for both primary and permanent dentition is normal, but does not resolve completely and therefore may form supern numerary teeth.
Abstract: The purpose of the present investigation was to describe the formation, maturation and eruption of the dentition, including supernumerary teeth in a sample of patients with cleidocranial dysplasia. The dentition was evaluated from orthopantomograms, intraoral radiographs, cephalometric films, surgically removed teeth and intraoral photographs in 19 patients (9 men, 10 women), aged 3.5 to 34 years. Formation of primary teeth was normal, whereas all patients but one had supernumerary permanent teeth. Frequency of supernumerary teeth ranged from 22% in the maxillary incisor region to 5% in the molar regions. Supernumerary teeth were formed lingually and occlusally to the normal teeth. Maturation of the primary dentition was normal, while permanent teeth were delayed from 1 to 4 yr. Supernumerary teeth were delayed about 4 years in relation to normal permanent teeth. Eruption of primary teeth was normal, whereas all patients had severe eruption problems of permanent teeth. It was hypothesized that the dental lamina for both primary and permanent dentition is normal, but does not resolve completely and therefore may form supernumerary teeth. Abnormalities of tooth morphology is related to inadequate space and arrested eruption. Delayed or arrested eruption is probably caused by diminished resorption of bone and of primary teeth and to the presence of multiple supernumerary teeth.

195 citations


Cited by
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Journal ArticleDOI
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.

2,066 citations

Journal ArticleDOI
TL;DR: Statistical shape models (SSMs) have by now been firmly established as a robust tool for segmentation of medical images as discussed by the authors, primarily made possible by breakthroughs in automatic detection of shape correspondences.

1,402 citations

Journal ArticleDOI
TL;DR: This review attempts to identify factors that influence shaping outcomes with nickel-titanium rotary instruments, such as preoperative root-canal anatomy and instrument tip design, and implications of various working length definitions and desired apical widths.

1,177 citations

Journal ArticleDOI
TL;DR: This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity.

1,052 citations

Journal ArticleDOI
TL;DR: An updated classification scheme based on molecular pathophysiology will bring greater clarity to discourse while catalyzing new hypotheses both at the bench and at the bedside, supplanting a clinical classification that has served well but is opaque to the genetic, immunologic, and therapeutic interrelationships now before us.
Abstract: The autoinflammatory diseases are characterized by seemingly unprovoked episodes of inflammation, without high-titer autoantibodies or antigen-specific T cells The concept was proposed ten years ago with the identification of the genes underlying hereditary periodic fever syndromes This nosology has taken root because of the dramatic advances in our knowledge of the genetic basis of both mendelian and complex autoinflammatory diseases, and with the recognition that these illnesses derive from genetic variants of the innate immune system Herein we propose an updated classification scheme based on the molecular insights garnered over the past decade, supplanting a clinical classification that has served well but is opaque to the genetic, immunologic, and therapeutic interrelationships now before us We define six categories of autoinflammatory disease: IL-1β activation disorders (inflammasomopathies), NF-κB activation syndromes, protein misfolding disorders, complement regulatory diseases, disturbances in cytokine signaling, and macrophage activation syndromes A system based on molecular pathophysiology will bring greater clarity to our discourse while catalyzing new hypotheses both at the bench and at the bedside

995 citations