S
Sverre E. Kjeldsen
Researcher at University of Oslo
Publications - 771
Citations - 95426
Sverre E. Kjeldsen is an academic researcher from University of Oslo. The author has contributed to research in topics: Blood pressure & Left ventricular hypertrophy. The author has an hindex of 94, co-authored 735 publications receiving 89059 citations. Previous affiliations of Sverre E. Kjeldsen include University of Michigan & Cornell University.
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Journal ArticleDOI
Pharmacogenetic implications for eight common blood pressure-associated single-nucleotide polymorphisms.
Viktor Hamrefors,Marketa Sjögren,Peter Almgren,Björn Wahlstrand,Sverre E. Kjeldsen,Thomas Hedner,Olle Melander +6 more
TL;DR: There are probably no important pharmacogenetic interactions for BP reduction with use of beta-blockers, diuretics or diltiazem, and nominally significant associations for rs12946454 and rs11191548 are true signals and could be of possible clinical relevance for deciding treatment of polygenic essential hypertension.
Journal ArticleDOI
Decreased peripheral dopaminergic activity in essential hypertension
TL;DR: In 42 men aged 50 +/- 1 years with untreated, sustained essential hypertension and in 34 age-matched normotensive men plasma free dopamine concentrations in venous blood in the standing position were more than 60% higher than supine values indicating dopamine involvement in the orthostatic response.
Insulin sensitivity relates to other cardiovascular risk factors in young men: validation of some modifications of the hyperinsulinaemic, isoglycaemic glucose clamp technique.
TL;DR: It is found that the modified isoglycaemic hyperinsulinaemic euglycaemic glucose clamp technique for assessing insulin sensitivity in skeletal muscle tissue is accurate and reproducible when performed in young/middle-aged men.
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Inter-regional comparisons of the prevalence of cardiometabolic risk factors in patients with hypertension in Europe: the GOOD survey.
TL;DR: The data indicate that many hypertensive patients across Europe have multiple cardiometabolic risk factors with the prevalence higher in Central Europe and the Atlantic European Mainland compared with Northwest and Mediterranean regions.
Journal ArticleDOI
Decreased Central Dopaminergic Activity in Essential Hypertension
Ingrid Os,Sverre E. Kjeldsen,Arne Westheim,Ingvar Aakesson,Nils Norman,Erik Enger,Ingvar Hjermann,Ivar Eide +7 more
TL;DR: An altered central dopaminergic activity in essential hypertension is indicated, even at rest, endogenous dopamine exerts a modulating effect on noradrenaline release in both hypertensive and normotensive men.