S
Syeed Hussain
Researcher at AstraZeneca
Publications - 2
Citations - 164
Syeed Hussain is an academic researcher from AstraZeneca. The author has contributed to research in topics: Fulvestrant & Estrogen receptor. The author has an hindex of 2, co-authored 2 publications receiving 130 citations.
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Journal ArticleDOI
Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-Fluoro-2-Methylpropyl)-3-Methyl-2, 3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indol-1-Yl)Phenyl)Acrylic Acid (Azd9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
Chris De Savi,Robert Hugh Bradbury,Alfred A. Rabow,Richard A. Norman,Camila de Almeida,David M. Andrews,Peter Ballard,David Buttar,Rowena Callis,Gordon S. Currie,Jon Curwen,Christopher D. Davies,Craig S. Donald,Lyman Feron,H. Gingell,Steven C. Glossop,Barry R. Hayter,Syeed Hussain,Galith Karoutchi,Scott G. Lamont,Philip A. MacFaul,Thomas A. Moss,Stuart E. Pearson,Michael Tonge,Graeme Walker,Hazel M. Weir,Zena Wilson +26 more
TL;DR: The discovery of an orally bioavailable selective estrogen receptor downregulator (SERD) with equivalent potency and preclinical pharmacology to the intramuscular SERD fulvestrant is described.
Journal ArticleDOI
Discovery of novel Jak2-Stat pathway inhibitors with extended residence time on target.
Guan Huiping,Michelle Lamb,Bo Peng,Shan Huang,Nancy DeGrace,Jon Read,Syeed Hussain,Jiaquan Wu,Caroline Rivard,Marat Alimzhanov,Geraldine Bebernitz,Kirsten Bell,Minwei Ye,Michael Zinda,Stephanos Ioannidis +14 more
TL;DR: The discovery of novel inhibitors of the Jak2/Stat5 axis, the N-(1H-pyrazol-3-yl)pyrimidin-2-amino derivatives are communicated, and the rationale, synthesis and biological evaluation of these derivatives are reported.