Sylvain Lefort

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: A new mechanism by which oxidative stress increases the migratory properties of stromal fibroblasts, which in turn potentiate tumour dissemination is uncovered, uncovering the relevance of the findings in human cancers.

TL;DR: It is demonstrated that LC3B, a protein involved in autophagosome formation, is a reliable marker of poor prognosis in TN BC, validating this prognostic value at both the mRNA and protein levels in several independent cohorts and the inhibition of autophagy is identified as a promising therapeutic strategy for TN BC patients.

TL;DR: The existence of antisense transcription exists in HIV-1 in the context of infection for the first time and a better characterization of the transcript and its regulation is provided.

TL;DR: In this article, the authors presented the first formal evidence of the shared and independent ability of basal cells and luminal progenitors, isolated from normal human mammary tissue and transduced with a single oncogene (KRAS(G12D)), to produce serially transplantable, polyclonal, invasive ductal carcinomas within 8 weeks of being introduced either subrenally or subcutaneously into immunodeficient mice.