S
Sylvie E. Blondelle
Researcher at Torrey Pines Institute for Molecular Studies
Publications - 108
Citations - 6425
Sylvie E. Blondelle is an academic researcher from Torrey Pines Institute for Molecular Studies. The author has contributed to research in topics: Peptide & Antimicrobial peptides. The author has an hindex of 39, co-authored 108 publications receiving 6269 citations. Previous affiliations of Sylvie E. Blondelle include Discovery Institute & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
Richard A. Houghten,Clemencia Pinilla,Sylvie E. Blondelle,Jon R. Appel,Colette T. Dooley,Julio H. Cuervo +5 more
TL;DR: The precise identification of an antigenic determinant recognized by a monoclonal antibody as well as the straightforward development of new potent antimicrobial peptides are presented.
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Design of model amphipathic peptides having potent antimicrobial activities
TL;DR: Using reversed-phase high-performance liquid chromatography as a means to study the secondary structure of peptides at aqueous/lipid interfaces, a sequence was found to readily adopt an amphipathic alpha-helical conformation upon interacting with the lipid groups of the stationary phase during RP-HPLC.
Journal Article
The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides.
Richard A. Houghten,Appel,Sylvie E. Blondelle,Julio H. Cuervo,Colette T. Dooley,Clemencia Pinilla +5 more
TL;DR: Examples are presented in which an SPCL, composed in total of 52,128,400 acetylated hexa-peptides, is used along with an iterative selection process to precisely identify the antigenic determinant of a peptide recognized by a monoclonal antibody using competitive enzyme-linked immunosorbent assay.
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Hemolytic and antimicrobial activities of the twenty-four individual omission analogues of melittin.
TL;DR: It was found that induced structural effects caused by peptide-lipid interactions could be studied by using RP-HPLC, with an excellent correlation found between the retention times of the individual omission analogues and their hemolytic activities.
Journal ArticleDOI
"Libraries from libraries": chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity
John M. Ostresh,G. M. Husar,Sylvie E. Blondelle,Barbara Dörner,Patricia A. Weber,Richard A. Houghten +5 more
TL;DR: The generation of diverse chemical libraries using a "libraries from libraries" concept using well-established solid-phase synthesis methods for the generation of combinatorial libraries, combined with the chemical transformation of such libraries while they remain attached to the solid support.