T. Gürpinar

Bio: T. Gürpinar is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Cystectomy & Interstitial cystitis. The author has an hindex of 1, co-authored 1 publications receiving 12 citations.

The prosthetic bladder

Abstract: Bladder reconstruction may be required in a variety of pathological conditions, including bladder cancer, irradiation cystitis, interstitial cystitis, tuberculosis, and various congenital anomalies. Currently, bladder reconstruction is done with an autogenous bowel segment. Use of a total prosthetic bladder as an intracorporeal urinary reservoir has been an elusive goal for many decades. Many investigational and a few clinical trials have been performed in an attempt to develop a near-nornal bladder prosthesis utilizing alloplastic materials. To date the ideal prosthetic bladder has not been developed. However, cumulative experimental studies suggest that many, perhaps all, of the ideal functional characteristics of a total prosthetic bladder are possible. Basically, two different alloplastic models have been investigated.

Alloplastic bladder substitution: are we making progress?

Abstract: Radical cystectomy with lymphadenectomy and urinary diversion is the gold standard treatment for bladder cancer in organ-confined muscle-invasive disease and selected patients who have high-grade non-muscle-invasive disease or are non-responders to BCG. The main and most morbid complications of this challenging surgery are related to the use of bowel for urinary tract reconstruction. For this reason, many past projects were devoted to finding an alternative to the use of bowel. The aim of this review is to provide a summary of the evolution of alloplastic bladder substitution. A comprehensive review of the literature was performed using the Medline National Library of Medicine database and Google Scholar. Keywords used were cystectomy and intestine/bowel, replacement, bladder substitution, organ replacement, artificial bladder, alloplastic material, biomaterial, and tissue engineering. Various prostheses have been proposed for replacement of the urinary bladder, silicone being the most frequently used material. The first published model of an alloplastic bladder was described by Bogash et al. in late 1959, while the last, in 1996, was suggested by Rohrmann. Interprofessional collaboration, recent advances in technology, and tissue engineering may help in developing suitable bladder prostheses. Urologists as well as engineers and the industry need to give this matter serious attention.

Le futur des biomatériaux en urologie

Abstract: Les champs d'application des biomateriaux implantes continuera a s'etendre allant de l'utilisation de catheters et frondes, pour l'appareil genito-urinaire, a la production de tissus et d'organes. L'echelle de recherche a change ces dernieres annees passant d'une vue macroscopique a une vue microscopique c'est ainsi que l'on est passe d'appareillages mecaniques, comme les protheses, catheters et frondes, a l'unite cellulaire et plus particulierement aux cultures cellulaires in vitro. De nouvelles techniques comme la therapie genique et la reconstruction cellulaire, sont apparues recemment dans le champ de l'urologie. Il est necessaire de realiser des etudes prospectives de biocompatibilite afin d'etablir des standards appropries de biocompatibilite adaptes aux nouveaux materiaux. Le developpement de ces nouveaux materiaux necessite une approche pluridisciplinaire impliquant ingenieurs, biologistes et physiciens. Il reposera sur des centres specialises avec une competence pour la recherche en biocompatibilite et une etroite cooperation entre les biosciences fondamentales et la pratique clinique. Les biomateriaux synthetiques, dans le futur, auront un champ quasi illimite de proprietes mecaniques leur permettant une application beaucoup plus specifique a l'usage souhaite. Il y aura aussi une amelioration des materiaux prenant en compte la reduction du risque infectieux, d'erosion, de depot mineral, de migration de particules et de reaction secondaire, enfin une durabilite amelioree. Toutefois les materiaux synthetiques ne pourront probablement pas avoir d'aussi bonnes proprietes a long terme que les biomateriaux naturels ou quasi naturels issus de la biotechnologie par genie tissulaire.