Author
T. Rajamannar
Bio: T. Rajamannar is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Alkylation & Ketone. The author has an hindex of 5, co-authored 16 publications receiving 81 citations.
Papers
More filters
TL;DR: In this article, the alkylation of bicyclo(2.2)oct-5-en-2-one (1) and intramolecular radical cyclisation towards the synthesis of functionalised tricyclic carbocycles is reported.
21 citations
TL;DR: A simple procedure for the C-alkylation of cyclic 1,3-diketones has been reported using Triton B as base in aqueous conditions.
18 citations
TL;DR: In this article, a facile method for the synthesis of 2-cyclopentenones from the acid-catalysed fragmentation of 7,7-dimethoxy 5-norbornen-2-ols and their derivatives is reported.
Abstract: A facile method for the synthesis of 2-cyclopentenones from the acid catalysed fragmentation of 7,7-dimethoxy 5-norbornen-2-ols and their derivatives is reported.
14 citations
TL;DR: Wieland-Miescher ketone analogues are prepared by monoalkylation of cyclohexane-1,3-dione with bromomethylcycloalkenyl bromides followed by annulation with methyl vinyl ketone; they undergo 5-exo-trig competitive intramolecular radical addition to the keto and enone olefins to give angularly rused carbocycles and propellanes, respectively as discussed by the authors.
Abstract: Wieland–Miescher ketone analogues are prepared by monoalkylation of cyclohexane-1,3-dione with bromomethylcycloalkenyl bromides followed by annulation with methyl vinyl ketone; they undergo 5-exo-trig competitive intramolecular radical addition to the keto and enone olefins to give angularly rused carbocycles and propellanes, respectively.
8 citations
TL;DR: In this paper, the exclusive formation of allenes and alkenols during the reduction of aryloxymethylethynylcarbinols and ethynyl carbinols respectively, with lithium aluminiumhydride, is reported.
6 citations
Cited by
More filters
TL;DR: This compilation clearly demonstrates the power and economical interest of asymmetric catalysed domino reactions in the field of synthetic organic chemistry including the asymmetric biocatalysed Domino reactions.
349 citations
189 citations
TL;DR: The regio- and stereoselective iodination of readily available acrylamides to access a variety of differently substituted Z-haloacrylic acid derivatives is reported, representing a rare example of a direct halogenation of electron-poor acrylic acid derivatives.
109 citations
TL;DR: The first example of the palladium-catalyzed coupling of vinylogous amides with aryl bromides and chlorides is described, which can be applied to high-yielding, one-pot syntheses of nitrogen-containing heterocycles.
85 citations
TL;DR: This work has discovered a highly efficient oxidative C-N bond forming reaction that relies on the union of a nitrogen anion and a carbon anion in the synthesis of the architecturally complex Lycopodium alkaloid lyconadin A.
Abstract: The formation of carbon−nitrogen (C−N) bonds is a fundamental bond construction in organic synthesis and is indispensable for the synthesis of alkaloid natural products. In the context of the synthesis of the architecturally complex Lycopodium alkaloid lyconadin A, we have discovered a highly efficient oxidative C−N bond forming reaction that relies on the union of a nitrogen anion and a carbon anion. Empirical evidence amassed during our synthetic studies suggests that the mechanism of the C−N bond forming process encompasses polar as well as radical processes. Herein, we present our study of this novel C−N bond forming reaction and its application to the enantioselective total synthesis of lyconadin A and related derivatives.
73 citations