Tadashi Inagami

TL;DR: Although AT(1) receptors mediate most of the known actions of Ang II, the AT(2) receptor contributes to the regulation of blood pressure and renal function and the development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system.

TL;DR: The results show that angiotensin II activates AT1 and AT2, which have mutually counteracting haemo-dynamic effects, and that AT2 regulates central nervous system functions, including behaviour.

TL;DR: The expression cloning of a complementary DNA encoding a bovine angiotensin II receptor is reported to overcome the difficulties faced in purifying the receptor owing to its instability and low concentration.

TL;DR: The expressed AT2 receptor mediated angiotensin II-induced inhibition of protein tyrosine phosphatase, an action that was dependent on a pertussis toxin-sensitive G-protein-coupled mechanism in COS-7 cells, and suggested novel functional roles of the renin-angiotens in system in cross-talk with phosphotyrosine signaling by modulating protein phosphotYrosine levels.

TL;DR: Data indicate that Ang II induces Ca2+-dependent transactivation of the EGF receptor which serves as a scaffold for pre-activated c-Src and for downstream adaptors, leading to MAPK activation in VSMC.