Author
Tadashi Nakata
Other affiliations: Saitama University, Toyohashi University of Technology, University of Tokyo ...read more
Bio: Tadashi Nakata is an academic researcher from Tokyo University of Science. The author has contributed to research in topics: Total synthesis & Ring (chemistry). The author has an hindex of 36, co-authored 276 publications receiving 4885 citations. Previous affiliations of Tadashi Nakata include Saitama University & Toyohashi University of Technology.
Papers published on a yearly basis
Papers
More filters
289 citations
140 citations
127 citations
TL;DR: In this article, the structure-stereoselectivity relationship between α-hydroxy ketones and zinc horohydride has been investigated and α-butyldiphenylsilyoxy derivatives with sodium bis(2methoxyethoxy)aluminum hydride gave the isomeric threoglycols.
123 citations
TL;DR: Erythro -3-hydroxy-2-alkylpropionates were prepared in high stereoselectivity and in high isolated yield by zinc borohydride reduction of the corresponding β-keto esters as discussed by the authors.
102 citations
Cited by
More filters
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
4,649 citations
TL;DR: The power of cascade reactions in total synthesis is illustrated in the construction of complex molecules and underscore their future potential in chemical synthesis.
Abstract: The design and implementation of cascade reactions is a challenging facet of organic chemistry, yet one that can impart striking novelty, elegance, and efficiency to synthetic strategies. The application of cascade reactions to natural products synthesis represents a particularly demanding task, but the results can be both stunning and instructive. This Review highlights selected examples of cascade reactions in total synthesis, with particular emphasis on recent applications therein. The examples discussed herein illustrate the power of these processes in the construction of complex molecules and underscore their future potential in chemical synthesis.
1,762 citations
1,378 citations
TL;DR: Michael reaction of malonates to nitrooleolefins with chiral bifunctional organocatalysts, bearing both a thiourea and tertiary amino group, afforded Michael adducts with high yields and enantioselectivities.
Abstract: Michael reaction of malonates to nitroolefins with chiral bifunctional organocatalysts, bearing both a thiourea and tertiary amino group, afforded Michael adducts with high yields and enantioselectivities (up to 95%, up to 93% ee).
1,202 citations
TL;DR: Examples of total syntheses in which metathesis reactions of olefins, enynes, and alkynes played a crucial role and which imparted to these endeavors certain elements of novelty, elegance, and efficiency are highlighted.
Abstract: With the exception of palladium-catalyzed cross-couplings, no other group of reactions has had such a profound impact on the formation of carbon-carbon bonds and the art of total synthesis in the last quarter of a century than the metathesis reactions of olefins, enynes, and alkynes. Herein, we highlight a number of selected examples of total syntheses in which such processes played a crucial role and which imparted to these endeavors certain elements of novelty, elegance, and efficiency. Judging from their short but impressive history, the influence of these reactions in chemical synthesis is destined to increase.
1,025 citations