T
Tadhg P. Begley
Researcher at Texas A&M University
Publications - 274
Citations - 14269
Tadhg P. Begley is an academic researcher from Texas A&M University. The author has contributed to research in topics: Active site & Cofactor. The author has an hindex of 60, co-authored 268 publications receiving 13221 citations. Previous affiliations of Tadhg P. Begley include Oregon State University & Boyce Thompson Institute for Plant Research.
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Journal ArticleDOI
The Subsystems Approach to Genome Annotation and its Use in the Project to Annotate 1000 Genomes
Ross Overbeek,Tadhg P. Begley,Ralph Butler,Jomuna V. Choudhuri,Han-Yu Chuang,Matthew P. Cohoon,Valérie de Crécy-Lagard,Naryttza N. Diaz,Terry Disz,Robert D. Edwards,Robert D. Edwards,Michael Fonstein,Ed D. Frank,Svetlana Gerdes,Elizabeth M. Glass,Alexander Goesmann,Andrew C. Hanson,Dirk Iwata-Reuyl,Roy A. Jensen,Neema Jamshidi,Lutz Krause,Michael Kubal,Niels Bent Larsen,Burkhard Linke,Alice C. McHardy,Folker Meyer,Heiko Neuweger,Gary J. Olsen,Robert Olson,Andrei L. Osterman,Vasiliy A. Portnoy,Gordon D. Pusch,Dmitry A. Rodionov,Christian Rückert,Jason Steiner,Rick Stevens,Rick Stevens,Ines Thiele,Olga Vassieva,Yuzhen Ye,Olga Zagnitko,Veronika Vonstein +41 more
TL;DR: The subsystem approach is described, the first release of the growing library of populated subsystems is offered, and the SEED is the first annotation environment that supports this model of annotation.
Journal ArticleDOI
Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-d-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol
Georg A. Sprenger,Ulrich Schörken,T Wiegert,Sigrid Grolle,A A de Graaf,Sean V. Taylor,Tadhg P. Begley,Stephanie Bringer-Meyer,Hermann Sahm +8 more
TL;DR: It is shown that an open reading frame at 9 min on the chromosomal map of E. coli encodes an enzyme (deoxyxylulose-5-phosphate synthase, DXP synthase) that catalyzes a thiamin diphosphate-dependent acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-ph phosphate to yield DXP.
Journal ArticleDOI
Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry.
Ying Ge,Brian G. Lawhorn,Mariam S. ElNaggar,Erick Strauss,Joo-Heon Park,Tadhg P. Begley,Fred W. McLafferty +6 more
TL;DR: The addition of ECD substantially increases the capabilities of top down mass spectrometry for the detailed structural characterization of large proteins.
Journal ArticleDOI
Thiamin biosynthesis in prokaryotes.
Tadhg P. Begley,Diana M. Downs,Steven E. Ealick,Fred W. McLafferty,Van Loon Ap,Sean V. Taylor,Nino Campobasso,Hsiu-Ju Chiu,Cynthia Kinsland,Jason J. Reddick,Jun Xi +10 more
TL;DR: The X-ray structures of thiamin phosphate synthase and 5-hydroxyethyl-4-methylthiazole kinase have been completed and the genes coding for the thienin transport system (thiBPQ) have been identified.
Journal ArticleDOI
The Structural and Biochemical Foundations of Thiamin Biosynthesis
TL;DR: Two thiamin degrading enzymes have been characterized and one of which is linked to a novel salvage pathway that can be salvaged through several routes, and the thiazole and pyrimidine moieties are synthesized in separate branches of the pathway.