T
Tae-Young Roh
Researcher at Pohang University of Science and Technology
Publications - 87
Citations - 18235
Tae-Young Roh is an academic researcher from Pohang University of Science and Technology. The author has contributed to research in topics: Chromatin immunoprecipitation & Epigenomics. The author has an hindex of 31, co-authored 79 publications receiving 16483 citations. Previous affiliations of Tae-Young Roh include National Institutes of Health.
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Journal ArticleDOI
High-resolution profiling of histone methylations in the human genome.
Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Dustin E. Schones,Zhibin Wang,Gang Wei,Iouri Chepelev,Keji Zhao +8 more
TL;DR: High-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology are generated.
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Combinatorial patterns of histone acetylations and methylations in the human genome
Zhibin Wang,Chongzhi Zang,Jeffrey A. Rosenfeld,Jeffrey A. Rosenfeld,Dustin E. Schones,Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Weiqun Peng,Michael Q. Zhang,Keji Zhao +11 more
TL;DR: The data suggest that a large number of histone modifications may act cooperatively to prepare chromatin for transcriptional activation and be associated with promoters and enhancers.
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Dynamic Regulation of Nucleosome Positioning in the Human Genome
Dustin E. Schones,Kairong Cui,Suresh Cuddapah,Tae-Young Roh,Artem Barski,Zhibin Wang,Gang Wei,Keji Zhao +7 more
TL;DR: It is found that nucleosome phasing relative to the transcription start sites is directly correlated to RNA polymerase II (Pol II) binding and the first nucleosomes downstream of a start site exhibits differential positioning in active and silent genes.
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Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells
Gang Wei,Lai Wei,Jinfang Zhu,Chongzhi Zang,Jane Hu-Li,Zhengju Yao,Kairong Cui,Yuka Kanno,Tae-Young Roh,Wendy T. Watford,Dustin E. Schones,Weiqun Peng,Hong-Wei Sun,William E. Paul,John J. O'Shea,Keji Zhao +15 more
TL;DR: Although modifications of signature-cytokine genes (Ifng, Il4, and Il17) partially conform to the expectation of lineage commitment, genes encoding transcription factors like Tbx21 exhibit a broad spectrum of epigenetic states, consistent with the demonstrated T-bet and interferon-gamma induction in nTreg cells.
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Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors
Su Chul Jang,Oh Youn Kim,Chang Min Yoon,Dong-Sic Choi,Tae-Young Roh,Jaesung Park,Jonas Nilsson,Jan Lötvall,Yoon-Keun Kim,Yong Song Gho +9 more
TL;DR: Bioinspired exosome-mimetic nanovesicles that deliver chemotherapeutics to the tumor tissue after systemic administration and removal of the plasma membrane proteins by trypsinization eliminated the therapeutic effects of the nanovesicle both in vitro and in vivo are suggested.